胺碘酮与伊贝沙坦对特发性阵发性心房颤动患者P波离散度的影响  

The observation of amiodarone and irbesartan on P wave dispersion and maximum P wave duration in patients with idiopathic paroxysmal atrial fibrillation

作　　者：潘伟彪[1] 兰军[1] 郭灼林[1] 

机构地区：[1]东莞市石龙人民医院心内科,广东东莞523321

出　　处：《中国基层医药》2005年第10期1346-1347,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察胺碘酮和伊贝沙坦对特发性阵发性心房颤动患者心电图P波离散度(Pd,ms)和最大P波时限(Pmax,ms)的影响。方法90例特发性阵发性心房颤动患者随机分为胺碘酮加伊贝沙坦组31例,伊贝沙坦组29例和胺碘酮组30例,健康对照组30例,观察药物治疗2个月前后心电图Pd和Pmax的变化。结果特发性阵发性心房颤动患者Pd和Pmax明显延长;胺碘酮加伊贝沙坦治疗前Pd(48±8)、Pmax(126±7),治疗后Pd(31±5)、Pmax(109±8);伊贝沙坦治疗治疗前Pd(47±9)、Pmax(126±6),治疗后Pd(44±7)、Pmax(120±9),但差异无显著意义;胺碘酮治疗前Pd(49±9)、Pmax(126±8),治疗后Pd(39±6)、Pmax(112±7),但对Pd和Pmax改善少于胺碘酮加伊贝沙坦组。结论胺碘酮加伊贝沙坦能显著降低特发性阵发性心房颤动患者P波离散度及P波最大时限。Objective To observe the effect of amiodarone and irbesartan on P wave dispersion（Pd,ms） and maximum P wave duration（Pmax,ms） in patients with idiopathic paroxysmal artrial fibrillation（IPAF）. Methods 90 patients with IPAF were divided into three groups. Group 1 were treated by amiodarone and irbesartan. Group 2 were treated by irbesartan. Group 3 were treated by amiodarone,Pd and Pmax were measured in all patients before and after 2 months of treatment. Results Pd and Pmax were higher significantly in patients with IPAF and were improved by amiodarong and irbesartan[Pd（48 ± 8）,Pmax（126 ± 8） vs Pd（39 ± 6） ,Pmax（109 ± 8）1. These data were also improved by amiodarone[ Pd（49 ± 9 ）, Pmax（ 126 ± 8） vs Pd（39 ± 6）, Pmax（ 112 ± 7）] but were no better than group 1 There were no change in group 2[Pd（47 ± 9） ,Pmax（126 ± 6） vs Pd（44 ± 7） ,Pmax（120 ± 9） 1. Conclusion Amiodarone and irbesartan can make the Pd and Pmax smaller significantly in patients with IPAF.

关 键 词：胺碘酮 伊贝沙坦 阵发性心房颤动 P波离散度 心房颤动患者 阵发性 特发性 最大P波时限 P波最大时限 药物治疗 

分 类 号：R541.7[医药卫生—心血管疾病]