复方金牡蛎胶囊在鸭乙型肝炎动物模型中的疗效观察  

Antiviral effect of oyster extract compound capsule in ducks infected by DHBV

作　　者：巫善明[1] 徐伟民[1] 徐征[1] 林锋[1] 盛莉 

机构地区：[1]上海市传染病医院肝炎临床研究室

出　　处：《中国药学杂志》1996年第5期304-307,共4页Chinese Pharmaceutical Journal

摘　　要：目的：采用鸭乙型肝炎动物模型考核复方金牡蛎胶囊的抗病毒作用和观察药物毒性等作用。方法：实验动物为垂直传播感染、ＤＨＢＶＤＮＡ检测阳性麻鸭，实验分设０．２，０．６和１．８ｇ／ｋｇ的不同剂量组和３个分别为ＤＨＢＶＤＮＡ（＋）、ＤＨＢＶＤＮＡ（－）和阿昔洛韦阳性药物对照组。给药为口腔途径喂饲，每周３次隔日给药，连续给药１２周。结果：不同剂量组血清ＤＨＢＶＤＮＡ平均含量在用药后均有不同程度下降，在停药后第２周时仍基本维持于停药时的水平。３个月的用药期间，各组分别有４～７只麻鸭血清ＤＨＢＶＤＮＡ转为阴性，其中高剂量组的转阴率达到５８％。病理观察有一定的病理改善作用，减轻炎症程度，尤以中、低剂量组的为明显，未发现药物有明显的肝脏病理毒性作用。结论：复方金牡蛎胶囊影响鸭乙肝病毒ＤＮＡ的复制，降低血清ＤＨＢＶＤＮＡ含量，有较明显的抗病毒作用。OBJECTIVE:To observe the results of a trial of oyster extract compound capsule administered to chronically infected,DHBV carrier ducks.METHOD:The ducks were infected as embryos in ovo by maternal transmission.Every 1 2 ducks were selected randomly in 7 2 ducks for six groups:three treatment groups of different dosage(0.2g/kg,0.69/kg and 1.8g/kg),DHBV DNA(+)group,DHBV DNA(-)group and positive drug (acyclovir)group. The treatment lasted three months. RESULTS:There were different reductions of circulating DHBV DNA in the treatment groups with different oyster extract dosages. Negative seroconversion of DHBV DNA in some ducks of treatment groups was observed during the treatment. It wasn’t observed that serum DNA level rebound in the ducks treated in the two-week follow-up period after treatment cessation. There was not any hepatic pathological toxicity observed by light and electron microscopy in the ducks treated with oyster extract compound capsule. CONCLUSION:Oyster extract compound capsule has the antiviral effect on inhibiting DHBV DNA replication.

关 键 词：复方 金牡蛎胶囊 乙型肝炎 动物模型 药物疗法 

分 类 号：R259.126.2[医药卫生—中西医结合] R286.87[医药卫生—中医内科学]