固相萃取GC－FID和GC－MS分析血浆中碱性药物  

SYSTEMATIC ANALYSIS OF BASIC DRUGS IN PLASMA USING X5-5 SOLID-PHASE EXTRACTION GC-FID AND GC-MS

作　　者：邱丰和[1] 刘力[1] 罗毅[1] 刘峰[1] 卢涌泉[1] 

机构地区：[1]军事医学科学院毒物药物研究所,军事医学科学院仪器测试中心

出　　处：《药学学报》1996年第4期296-299,共4页Acta Pharmaceutica Sinica

摘　　要：报道了用Ｘ－５固相萃取分离、毛细管ＧＣ－ＦＩＤ和ＧＣ－ＭＳ定性定量分析人血浆中３４种碱性药物的方法。在优化的提取条件下，大部分药物的最低检测浓度在０．５～２．０μｇ·ｍｌ－１之间，线性范围、定量精密度等满足临床中毒分析的要求。A systematic determination method for 34 hasic drugs in human plasma isdescribed. Drugs were extracted from plasma at pH 10 using X-5 resin as adsorbent,then identifiedand quantitated by capillary GC-FID and GC-MS.The detection limits for most drugs are in the rangeof0.5～2.0μg·ml-1.Precision and linearity of the method are satisfactory for clinical toxicologicalapplications.

关 键 词：碱性药物 固相萃取 GC-FID GC-MS 药物中毒 

分 类 号：R595.404[医药卫生—内科学]