睾丸酮、雌二醇和棉酚合并用药的雄性抗生育作用及其安全性的研究  

THE ANTIFERTILITY EFFECT OF GOSSYPO PLUS TESTOSTERONE AND ESTEROGEN

作　　者：叶惟三[1] 但凌[1] 郭燕[1] 钱晓菁[1] 应骏 薛社普[1] 

机构地区：[1]中国医学科学院,中国协和医科大学基础医学研究所

出　　处：《药学学报》1996年第4期313-315,共3页Acta Pharmaceutica Sinica

基　　金：计生委科研基金

摘　　要：睾丸酮、雌二醇和棉酚合并用药的雄性抗生育作用及其安全性的研究叶惟三，但凌，郭燕，钱晓菁，应骏，薛社普（中国医学科学院，中国协和医科大学基础医学研究所，北京１００００５）减轻有抗男性生育活性棉酚的副作用是发展棉酚成为男性避孕药急待解决的问题［１，２］。...In order to reduce the side effect of gossypol, gossypol was used in combinationwith steroid hormones so that the dose of both drugs can be reduced. Silastic capsules containingtestosterone (T)+estradiol (E) were implanted under the skin male wister rats for 8 weeks. Afterremoving the implants , testosterone was given orally at the dose of 15 mg·kg-1 which is only 50% ofthe usual antifertility dose. Mating tests showed that the male rats became infertile. Microscopicexamination of the heart, liver and kidneys showed no pathologic changes. The treated rats gainedthey weight as well as the controls. The fertility of the treated rats recovered four to five weeks aftertreatment. Thus, gosaypol in combination with testosterone and estrogen exhibited a low degree of sideeffect and high antifertility activity.

关 键 词：避孕药 睾丸酮 雌二醇 棉酚 男性 

分 类 号：R979.21[医药卫生—药品]