乙型肝炎患者血清TNFα、IL-6和IL-8检测及临床意义  

Measurement of serum TNFα,IL-6 and IL-8 levels and its significance in patients with chronic hepatitis B

作　　者：杨子安 吕建南 何秀岩 付纯芳[2] 

机构地区：[1]大庆市第二人民医院,黑龙江大庆163000 [2]佳木斯大学机能教研室,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2005年第5期39-40,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:研究血清肿瘤坏死因子α(TNFα)白细胞介素-6(IL-6)和白细胞介素-8(IL-8)水平与慢性乙型肝炎(CHB)的关系。方法:采用放射免疫分析法(R IA)检测了65例CHB患者及30例健康人血清IL-1β、IL-6及IL-8的浓度。结果:CHB患者血清TNFα、IL-6和IL-8水平均显著高于正常对照组(P<0.01),CHB患者TNFα、IL-6和IL-8水平增高与病情严重程度呈正相关(P<0.01)。结论:TNFα、IL-6和IL-8参与CHB免疫病理损伤过程,检测血清TNFα、IL-6和IL-8在判断CHB患者肝损伤程度及预后有临床实用价值。Objective： To study the relationship between serum TNFα, IL-6 and IL-8 levels in patients with chronic hepatitis B（CHB）. Methods：The serum TNFα, IL-6 and IL-8 levels in 65 patients with CHB and 30 normal controls were measured by radioimmunoassay. Results：The TNFα, IL-6 and IL -8 levels were significantly higher than those of normal controls （ P 〈 0.01 ）. A positive relation was found between serum TNFα, IL-6 and IL-8 levels. Conclusion： TNFα, IL-6 and IL-8 participate in the injury course of CHB immune, and the measurement of serum TNFα, IL-6 and IL-8 levels has clinical value for the judgement of CHB patient＇s condition and their prognosis.

关 键 词：慢性乙型肝炎 肿瘤坏死因子Α 白细胞介素-6 白细胞介素-8 

分 类 号：R512.62[医药卫生—内科学]