阿比朵尔对小鼠的免疫调节作用  

Immunity Modulating of Arbidol Hydrochloride in Mice

作　　者：周一平[1] 蒋景仪[2] 陈四艳[1] 陈奇有[1] 孙雪冰[2] 杨静华[1] 

机构地区：[1]湖北省医药工业研究院药理毒理实验中心,武汉430061 [2]中国医学科学院医药生物技术研究所,北京100050

出　　处：《医药导报》2005年第11期989-991,共3页Herald of Medicine

基　　金：国家九五攻关项目(基金编号:96-902-01-22)

摘　　要：目的观察阿比朵尔(Ar)对小鼠的干扰素诱导和免疫调节作用. 方法观察3种剂量Ar灌胃对正常小鼠不同时间血清干扰素(IFN)含量的影响,对正常小鼠腹腔巨噬细胞吞噬百分率和吞噬指数、对氢化可的松(Hc) 形成免疫功能低下小鼠的碳廓清指数和迟发型超敏反应、对正常和环磷酰胺(Cy)所致免疫低下小鼠血清溶血素含量的影响.结果小鼠给予Ar后6～24 h,血清中均出现INF,高峰在用药后18 h.Ar灌胃5 d使正常小鼠腹腔巨噬细胞吞噬功能增强,使免疫低下小鼠碳廓清指数和迟发型超敏反应增强,使正常小鼠和免疫低下小鼠血清溶血素含量升高.结论 Ar对小鼠具有明显的体内诱生干扰素作用,对正常和免疫低下小鼠的非特异性免疫功能、体液和细胞免疫功能具有增强作用.Objective To observe the effects of arbidol hydrochloride （Ar） on interferon inducing and immunity modulating in mice. Method The mice were intragastrically given Ar of 100, 50 or 25 mg · kg^-1. Then the serum interferon were timely determined after a single Ar administration. The rate of abdominal phagocytosis of macrophage in normal mice, the index of phagocytosis, the carbon particles clearance index and delayed type hypersensitivity in immune-suppressed mice induced by Hydrocortisone （ Hc ）, and the contents of serum hemolysin both in normal and immune-suppressed mice induced by Cyclophosphamide （Cy） were detected. Results The interferon contents were detected in 6 - 24 h after Ar administration, and the maximum peak was in 18 h. An increased phagocytosis of peritoneal macrophage in normal mice, the enhanced carbon particles clearance index and delayed type hypersensitivity in immune-suppressed mice induced by Hc and the higher contents of serum hemolysin both in normal and immune-suppressed mice induced by Cy were observed with the administration of Ar for 5 d. Conclusion Ar exerts enhancing effects on interferon induction in vivo and on immunity function both in specifically and nonspecifically.

关 键 词：阿比朵尔 干扰素 免疫调节 小鼠 

分 类 号：R978.7[医药卫生—药品] R965[医药卫生—药学]