HIV/AIDS致病机理研究进展  

Pathogenic Mechanism of HIV/AIDS:Progress in Study

作　　者：石艳春[1] 梁浩[1] 郑源强[2] 

机构地区：[1]哺乳动物生殖生物学及生物技术教育部重点实验室 [2]河北省华北煤炭医学院生物科学系,河北唐山063000

出　　处：《内蒙古医学杂志》2005年第10期908-911,共4页Inner Mongolia Medical Journal

摘　　要：目的:对近年来获得性免疫缺陷综合征(Acquired Immunodeficiency Syndrome,AIDS)的致病机理研究进展进行综述。方法:参阅新近公开发表的中外文献阐述了AIDS是由人类免疫缺陷病毒(HumanImmunodeficiency Virus,HIV)引起的一种严重的免疫缺陷性疾病。结果:HIV属于逆转录病毒,由双链RNA、病毒核心蛋白及包膜组成,分为两种类型(HIV-1,HIV-2),绝大多数感染人体的是HIV-1。HIV通过病毒糖蛋白gp120/gp41与在被感染细胞的细胞膜表面同时表达的CD4和辅助受体进行识别,从而侵入细胞并损伤宿主的免疫系统,而宿主的免疫应答又不能清除HIV,最终发展成AIDS。结论:HIV感染最终导致机体的免疫功能的损伤,进而发展成AIDS。本文就AIDS致病机理的研究进展做一简要的综述。Objective:To review the pathogenic mechanism of acquired immunodeficiency syndrome(AIDS).Methods:The references home and aboard showed that AIDS was a severe immunodeficiency disease caused by infection with HIV.Results:HIV particle was a retrovirus which consisted of two identical strands of RNA,core protein and envelope.HIV was grouped into two categories:HIV-1 and HIV-2.Most bodies were infected by HIV-1.HIV infected cells presenting both CD4 and coreceptor which binded to the viral gp^(120)/go^(41).AIDS developed when HIV destroied the host immune system while the host immune response could not eradicate HIV infection.Conclusion:HIV infection destroies the immune system and develops AIDS.This paper reviews the studies on pathogenic mechanism of AIDS.

关 键 词：HIV AIDS CIM^+T细胞 辅助受体 

分 类 号：R392.11[医药卫生—免疫学]