冠心病人联合检测MMP-9,LDL-c的意义  

Significance of Joint Detection of Matrix Metalloproteinase-9 and LDL-C in Patients with Coronary Artery Disease

作　　者：王振国[1] 曹小敏[1] 王燕舞[1] 

机构地区：[1]解放军第260医院内二科,河北石家庄050043

出　　处：《临床军医杂志》2005年第5期532-534,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨联合检测MMP9,LDLc对不同类型冠心病人危险分层的意义。方法测定20例急性心肌梗死(AMI)患者、30例不稳定性心绞痛(UAP)患者、30例稳定性心绞痛(SAP)患者及30例造影正常者(对照组)血清MMP9,LDLc水平。结果急性冠脉综合征患者血清MMP9水平显著升高,与SAP患者及对照组相比均有显著差异。冠心病人LDLc水平高于对照组,有显著差异。在LDLc水平升高的患者中血清MMP9水平升高更明显。结论联合检测MMP9,LDLc对不同类型冠心病人危险分层、尽早发现ACS可提供帮助。Objective To evaluate the significance of joint detection of matrix metalloproteinase-9 （MMP-9） and low-density lipoprotein-C （LDL-C） on the danger degree assessment of coronary artery disease （CAD）. Methods Detection of MMP-9 and LDL- C in serum level was performed in 30 patients with stable angina peetoris （SAP） , 20 patients with acute myocardial infarction （ AMI）, 30 patients with unstable angina pectoris （UAP） and 30 age-matched individuals with negative angiographie findings. Results The serum level of MMP-9 was remarkably increased in the patients with acute coronary artery syndrome （ACS） when compared with that of SAP and normal control group （ P 〈 0.05 ）. The serum level of LDL-C was remarkably increased in the patients with coronary artery disease （ P 〈 0.05 ）. The serum level of MMP-9 of the patients whose LDL-C level was higher than normal was much higher （ P 〈 0.05 ）. Conclusion Joint detection of MMP-9 and LDL-C may be helpful to assessing danger degree ot coronary artery disease. In this way, we can find and cure CAD patients at high risk earlier.

关 键 词：冠心病 急性冠脉综合征 低密度脂蛋白类 

分 类 号：R541.4[医药卫生—心血管疾病]