颈动脉粥样硬化斑块内ICAM-1表达的研究  

Study on Expression of ICAM-1 in the Carotid Atherosclerotic Plaques

作　　者：李华[1] 蒲传强[1] 门保忠[2] 周定标[2] 

机构地区：[1]北京中国人民解放军总医院神经内科,南京军区总医院神经内科100853 [2]北京中国人民解放军总医院神经外科,100853

出　　处：《脑与神经疾病杂志》2005年第5期337-339,329,共4页Journal of Brain and Nervous Diseases

摘　　要：目的：观察颈动脉粥样硬化(AS)斑块内细胞间粘附分子-1(ICAM-1)的mRNA和抗原的表达情况。方法：分别应用原位杂交和免疫组织化学测定颈AS斑块中ICAM-1mRNA和抗原表达。结果：相对于正常动脉内膜，颈AS病变内膜ICAM-1阳性细胞数明显增多(P<0．05)。其中颈AS严重病变肩区阳性细胞数最多，以单核-巨噬细胞为主。结论：ICAM-l与颈AS发生密切相关。Objective： To observe the mRNA and antigen expression of ICAM-lin the carotid atherosclerotic plaques area. Methods： Antigen and mRNA of ICAM-1 weremeasured by immunocytochemistry and hybridization in situ respectively. Results：ICAM-1 positive cells in the intimas of the Carotid AS plaques increased than thosein the intimas of the normal arterial walls. There were the most ICAM-1-positive cellsin the shoulder areas of the advanced lesions. The positive cells in the shoulder areaswere mainly monocytes and macrophages. Conclusion： ICAM-1 May be associated withthe carotid atherosclerosis.

关 键 词：颈动脉 动脉粥样硬化 细胞间粘附分子 ICAM-1MRNA 颈动脉粥样硬化斑块 动脉粥样硬化(AS) 表达的研究 单核-巨噬细胞 抗原表达 动脉内膜 

分 类 号：R512.3[医药卫生—内科学] R543.4[医药卫生—临床医学]