大剂量5α还原酶抑制剂对雄性大鼠生精功能的影响  

Effect of Large-dosage of 5α-reductase Inhibitors on the Spermatogenesis of Male Rats

作　　者：王晓东[1] 贾悦[1] 崔毓桂[1] 王兴海[2] 童建孙 马鼎志 蔡瑞芬[2] 狄福松[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029 [2]江苏省计划生育研究所,江苏南京210037

出　　处：《中华男科学杂志》2005年第9期652-654,共3页National Journal of Andrology

基　　金：江苏省135医学重点人才项目(RC20022076)

摘　　要：目的:研究高选择性5α还原酶抑制剂(爱普列特)在较大剂量时对雄性SD大鼠生精功能的影响。方法:32只8周龄雄性SD大鼠随机分为喂服淀粉的空白对照(C)组、喂服爱普列特1 mg/d(EL)组、喂服爱普列特5mg/d(EH)组及喂服非那甾胺(F)组,每组8只。观察大鼠睾丸重量、血清睾酮和双氢睾酮水平、附睾精子计数和配对雌性大鼠妊娠阳性数等变化情况。结果:与C组相比,F组或EH组均有①抑制前列腺生长和减轻睾丸重量的作用(P<0.05);②降低血清双氢睾酮而升高睾酮水平;③抑制大鼠精子数量,同时影响雄性大鼠生育能力。结论:大剂量高选择性5α还原酶抑制剂(爱普列特)可抑制雄性SD大鼠前列腺、睾丸重量,抑制精子生成并降低雄性大鼠生育力。Objective： To identify the role of 5α-reductase in the spermatogenesis of male rats by studying the effect of two 5α-reduc- tase inhibitors, Epristeride and Finasteride, on the spermatogenesis in male Sprague-Dawley （SD） rats. Methods： Changes in the weight of the testis, serum testosterone and dihydrotestosterone levels, epididymal sperm count, and reproductive function were observed and analyzed after the two 5α-reductase inhibitors were administered to male SD rats orally. Results： The experiment showed that in comparison with control animals, both the two 5α-reductase inhibitors： ① suppressed the development of the prostate and reduced the weight of the testis in the experimental groups（ P〈0.05 ） ;② decreased the serum level of dihydrotestosterone and enhanced testosterone ; ③ inhibited epididymal sperm count and productive function. Conclusion ： High dosages of the 5ct-reductase inhibitor, Epristeride, can suppress the development of the prostate and reduce the weight of the testis, decrease dihydrotestosterone, and inhibit spermatogenesis and productive function in male rats.

关 键 词：5Α还原酶抑制剂 生精功能 雄性大鼠 

分 类 号：R96[医药卫生—药理学]