灵芝提取物对人肝癌SMMC─7721细胞DNA合成的影响  

THE EFFECT OF EGL ON THE DNA SYNTHESIS OF HUMAN HEPATOMA CELL LINE SMMC-7721

作　　者：徐朝晖[1] 姜世明[1] 

机构地区：[1]山东师范大学生物系

出　　处：《中国食用菌》1996年第1期34-35,共2页Edible Fungi of China

摘　　要：本文以人肝癌ＳＭＭＣ－７７２１细胞为材料，对水溶性灵芝提取物（ＥＧＬ）抗癌作用机理进行了研究。结果表明，ＥＧＬ能明显抑制ＳＭＭＣ－７７２１细胞的ＤＮＡ合成：ＥＧＬ在５０ｕｇ／ｍｌ到３００ｕｇ／ｍｌ范围表现出明显的剂量效应；ＥＧＬ最小有效作用剂量为１００ｕｇ／ｍｌ，最大有效作用剂量为３００ｕｇ／ｍｌ。结果提示ＥＧＬ的抗癌机理主要是通过抑制癌细胞ＤＮＡ合成而起作用的。In this paper,the effect of EGL (Extraction of Ganoderma lucidum)on the DNA synthesis of human hepatoma cell line SMMC-7721 was studied,The results demonstrated that(1)the EGL could significantly inhibite the DNA synthesis of SMMC-7721 cells.(2)The inhibitory activity showed a possitive dose relativity from 50ug EGL/ml to 300ug EGL/ml/(3)The minimum active dose of EGL was l00ug/ml,the maximum was 300 ug/ml.From the results, we could conclude that the anticancer activity of the EGL was mainly by inhibiting DNA synthesis of the cancer cells.

关 键 词：芝灵 人肝癌细胞 DNA合成 抗癌机理 

分 类 号：R286.91[医药卫生—中药学]