中药组方作为血管栓塞剂的实验研究  

Experimental studies of formulated Chinese medicinal herbs as a vascular embolizing agent

作　　者：沈俊杰[1] 陈自谦[1] 王曙东[2] 郑晓刚[3] 曹建民[1] 

机构地区：[1]南京军区南京总医院医学影像科,江苏南京210002 [2]南京军区南京总医院制剂科,江苏南京210002 [3]南京军区南京总医院病理科,江苏南京210002

出　　处：《医学研究生学报》2005年第10期893-895,i0007,共4页Journal of Medical Postgraduates

摘　　要：目的:研究中药组方作为血管栓塞剂的有效性、安全性及相关特性,以期获得一种理想的肿瘤血管栓塞剂。方法:将根据药典提供的数味具有抗癌和促凝作用的中草药制成具有一定黏滞性、不透X线、易经各种介入用导管注入动脉的混悬液栓塞剂。对其进行一系列有关特性的研究和鉴定,并应用其对8头健康猪进行肝动脉栓塞实验。结果:该栓塞剂具有良好的血液相容性和组织相容性,无致热原性及毒性作用;栓塞部位主要是末梢小动脉,栓塞牢靠,维持时间可达5周,不易形成侧支循环;经光镜和电镜观察证明其对正常肝组织损伤轻微,仅出现栓塞部位的肝细胞空泡变性和细胞质灶性坏死。结论:中药组方栓塞剂具有良好的血管栓塞作用,使用方便、安全,是一种较理想的末梢型血管栓塞剂。Objective： To study the efficacy, safety and relative characteristics of formulated Chinese medicinal herbs as a vascular embolizing agent. Methods： We prepared a mixture as a vascular embolizing agent from several Chinese medicinal herbs, they served as anticarcinogen and/or coagulant according to the Chinese Pharmacopeia. We studied the characteristics of the mixture through embolizing the hepatic artery in eight pigs with it. Results： The mixture was prepared as a suspension. It was easily injected through catheters and showed good histocompatibility and hemo-compatibility without pyrogenetic response and toxicity. The mixture mainly embolized peripheral arteries, maintaining occlusion for 5 weeks and without formation of collateral circulation. We found injuries of normal hepatic tissues as slight hepatocyte hydrops and focal endochyloma necrosis through optical and electronic microscope. Conclusion： This suspended mixture of Chinese medicinal herbs is safe and effective as a potential peripheral embolizing agent.

关 键 词：中草药 组方 动物实验 栓塞剂 

分 类 号：R543[医药卫生—心血管疾病]