森林脑炎纯化疫苗接种反应和免疫学效果观察  

Adverse Reaction and Immunological Effect of Purified Tick-borne Encephalitis Vaccine

作　　者：董关木[1] 宋宗明[2] 刘文雪[1] 安祺[1] 王晓理 王显军 韩亮[2] 涛波 孔艳[1] 杨立宏[1] 

机构地区：[1]中国药品生物制品检定所,北京100050 [2]长春生物制品研究所,长春130062 [3]内蒙古自治区疾病控制中心,呼和浩特010000 [4]山东省省疾病控制中心,济南250000

出　　处：《中国生物制品学杂志》2005年第6期514-515,共2页Chinese Journal of Biologicals

摘　　要：目的观察森林脑炎纯化疫苗接种反应和免疫效果。方法选择目标人群,并用原制疫苗作对照,观测疫苗注射后的反应,并采集疫苗免疫前后血清,用蚀斑减少法检测中和抗体,评价疫苗的免疫效果。结果森林脑炎纯化疫苗接种后无全身副反应,局部反应率仅为0.82%。血清中和抗体阳转率高于85%。结论森林脑炎纯化疫苗较原制同类疫苗反应轻微,而中和抗体阳转率明显高于原制疫苗,是现用原制灭活疫苗理想的替代产品。Objective To observe the adverse reaction and immunological effect of purified tick-borne encephalitis vaccine.Methods Immtmize the subjects with purified tick-borne encephalitis vaccine, using the original vaccine as control, Observe the adverse reactions after immunization and determine the antibody by plaque reduction neutralization test.Results No systemic reaction was observed,and the local reaction rate was only 0.82% .The serum neutralizing antibody positive eonversion rate was more than 85% .Condusion Compared with those induced by original vaccine, the adverse reaction induced by the purified vaccine was mild,and the neutralizing antibody positive conversion rate was high.Purified tick-borne encephalitis vaccine might be an ideal substitute of original inanfivated vaccine.

关 键 词：森林脑炎 纯化疫苗 接种反应 免疫学 副反应 临床试验 

分 类 号：R512.34[医药卫生—内科学] R186[医药卫生—临床医学]