止痛灵片的时辰药动学研究  

tudy of chrono-pharmacokinetics of Zhitongling tablets

作　　者：安彩贤[1] 刘力[1] 薛春霞[1] 屈清慧[1] 符军梅 杨广德[1] 

机构地区：[1]西安医科大学药学系

出　　处：《西北药学杂志》1996年第1期25-27,共3页Northwest Pharmaceutical Journal

摘　　要：６名健康受试者子不同时辰（１２：００，０：００）口服５００ｍｇ止痛灵片，以紫外分光光度法测定尿药浓度进行药代动力学研究。经ＰＫＢＰ－Ｎ１程序拟合表明，止痛灵片在人体的处置过程符合一室模型。该片剂在人体内无明显昼夜节律变化。The chrono-pharmacokinetics of Zhitongling tablets was studied. Sixhealthy men took 500mg orally at different time (12: 00, 0: 00). The urine samples were detected by UV spectrophotometry. The data were treated by PKBP-N1 program. The results showed that this drug was one-compartment model and CP, TP and AUC were nodifferent statistially on chrono-pharmacokinetics.

关 键 词：止痛灵片 紫外分光光度法 时辰药动学 

分 类 号：R971.1[医药卫生—药品] R969.1[医药卫生—药学]