胆碱能M和N受体激动剂和阻断剂对铅中毒大鼠记忆能力的影响  

Effects of cholinergic agonistand antagonists on lead-iuduced memory impairmentin rat.

作　　者：肖杭[1] 杨永年[1] 程健[1] 陆巍[1] 姜允申[1] 

机构地区：[1]南京医科大学应用毒理学研究所神经行为毒理实验室

出　　处：《职业医学》1996年第1期7-8,共2页China Occupational Medicine

摘　　要：本文观察了铅梁毒对大鼠长期记忆保存能力的影响，并经侧脑室给予胆碱能Ｍ、Ｎ受体激动剂和阻断剂，观察其对铅毒性的作用。结果显示：铅可明显损害大鼠对迷宫光亮分辨记忆的保存能力。Ｍ受体激动剂乙酰胆碱和阻断剂阿托品可分别显著改善和加重铅对长期记忆的损害，Ｎ受体激动剂烟碱亦有改善作用，但未见Ｎ受体阻断剂六烃季胺加重记忆损害的现象，这提示胆碱能Ｍ和Ｎ受体均在铅对大鼠长期记忆的影响中起作用，但其重要性和特性有所不同。he effects of icv cholinergic agonists(acetyl-choline 6 μg,nicotine 20μg)and cholinergic antagonists(atropine 20μg,hexahydrosiladifenidol 250μg)on leadto impair consolidation of memory in 96 rats werestudied.The results showed significeant memory im-pairments in lead intoxicated rats. Acetvlcholine andnicotine could markedly increase the consnlidation ofmemory.M receptor cholinergic antagonist atropineaggravate impairment of memory,N receptor choli-nergic antagonist hexahydrosiladifenidol could not ag-gravate the lead effect, The results indicated that theM receptor have more important action than N recep-tor in rat hippocamp area on lead-induced memory im-pariment.

关 键 词：铅 记忆保存 胆碱能受体 铅中毒 

分 类 号：R135.11[医药卫生—劳动卫生]