抗骨松冲剂对维甲酸所致大鼠骨质疏松症的防治作用  

Effect of Kanggusong in Prevention and Treatment of Retinoic Acid induced Osteoporosis in Rats

作　　者：吴波[1] 徐冰[1] 黄添友[1] 王金锐 

机构地区：[1]深圳三九集团医药研究院药理室

出　　处：《中国中西医结合杂志》1996年第1期32-36,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：给大鼠灌服维甲酸１４天后２周发生明显的骨质疏松症。在灌服维甲酸同时给予高（３．０ｇ·ｋｇ－１·ｄ－１）、中（１．０ｇ·ｋｇ－１·ｄ－１）、低（０．５ｇ·ｋｇ－１·ｄ－１）剂量的抗骨松冲剂，结果中、高剂量的抗骨松冲剂能明显抑制维甲酸引起的胫骨骨小梁和密质骨骨量丢失，骨小梁面积百分数和密质骨面积百分数较模型组比较均明显增加（Ｐ＜０．０５或Ｐ＜０．００１），恢复到正常对照组水平；还能明显改善骨显微结构的病理变化，使骨小梁厚度（高剂量）明显增加（Ｐ＜０．０５），骨小梁间隙和骨髓腔明显缩小（Ｐ＜０．０５）。其机理与它抑制破骨细胞活性，激活成骨细胞功能，使骨代谢处于骨形成大于骨吸收的正平衡状态，以及升高血钙和血中雌激素浓度，对抗维甲酸损伤性腺等作用有关。Retinoic acid 70 mg/kg . d was given by gastrogavage to Wistar rat for 14 days to induce osteoporosis. Kanggusong(KGS), a mixture of extracts from 8 traditional Chinese drugs, was given to 3 test groups of rats simultaneously in various dosage. Results showed that the KGS displayed obvious action in preventing osteoporosis, the trabecular loss of tibiae and bone loss of compact bone were lowered markedly in KGS groups with high (3.0 g/kg . d) or middle (1.0 g/kg . d)dosage in comparing with control model group, the trabecular area percentage and compact bone area percentage were increased significantly(p ＜0.05) which approached to the level of normal control group. KGS could also improve the pathological changes in microstructure of bone,increase the thickness of trabecula and cortex (P ＜0.05) , reduce the trabecular gap and bone marrow cavity (P＜0 . 05) . The mechanism of KGS might be relevant with its action of suppressing　the osteoclast activity and activating osteoblast, resulting a positive balance of bone metabolism, increasing the blood concentration of calcium and estrogen as well as its antagonistic action against the injury of sex glands by retinoic acid.

关 键 词：抗骨松冲剂 维甲酸 骨质疏松 防治 

分 类 号：R681.01[医药卫生—骨科学]