静吸复合全麻中阿芬太尼对血流动力学的影响  

Hemodynamic effects of aifentanil during combined general anesthesia in human

作　　者：李钊[1] 靳凤玲[1] 金清尘[1] 杨宣 

机构地区：[1]北京医科大学第三临床医院麻醉科,100083

出　　处：《中华麻醉学杂志》1996年第2期65-67,共3页Chinese Journal of Anesthesiology

摘　　要：观察阿芬太尼用于静脉复合麻醉对于气管插管时及术中、术后循环的影响。选择ASA Ⅰ～Ⅱ级择期手术患者40例:实验组(A组)20例,用阿芬太尼40μg·kg^(-1)诱导,维持量每分钟1μg·kg^(-1);对照组(B组)20例,用芬太尼4μg·kg^(-1)诱导,维持量每分钟0.1μg·kg^(-1),维持期均吸入1%～1.5%安氟醚,酌情追加维库溴铵。分别记录两组入室时、给诱导量后1～5分钟、插管后0～2分钟及拔管后0～10分钟的血压(收缩压、舒张压、平均压)、心率变化。实验结果表明阿芬太尼40μg·kg^(-1)能抑制插管时的心血管反应,1μg·kg^(-1)·min^(-1)用于静吸复合全麻时,维持手术中循环稳定,术后呼吸恢复快,因此适于作静点维持麻醉。The influences of alfentanil on the iutubation response and the homodynamic changes during and after operation were studied. 40 patients (ASA Ⅰ～Ⅱ) were randomly divided into study group (n=20) and control group (n=20). The patients recieved alfentanil 40μg·kg^(-1)(study group) or fentanyl 4μg·kg^(-1)(control group) for induction and alfentanil 1μg·kg^(-1)·min^(-1) or fentanyl 0.1μg·kg^(-1)·min^(-1). with 1%～1.5% enflurane for mamtenance of anesthesia. respectively. SP, DP, MAP, HR were recorded before and 1～5 min after induction, 0～2 mins after intubation. The results showed that the intubation responses can be depressed by atfentanil 40μg·kg^(-1) and hemodynamics were stable during and after anesthesia with alfentanil 1μg·kg^(-1)·min^(-1) and 1%～1.5% enflurane. It is suggested that the alfentanil can be used for induction as well as for maintenance of anesthesia.

关 键 词：阿芬太尼 芬太尼 静吸复合麻醉 心血管反应 

分 类 号：R971.2[医药卫生—药品]