Ets-1在原发性卵巢癌中的表达及其与微血管密度的关系  

Expression of E26 transformation-specific-1 and its Correlations with Microvessel density in primary ovarian carcinoma

作　　者：周金年[1] 肖子文[1] 蔡华蕾[1] 成元华[2] 

机构地区：[1]贵阳医学院附属医院妇产科,550004 [2]贵阳医学院病理学教研室,550004

出　　处：《贵州医药》2005年第11期966-968,共3页Guizhou Medical Journal

摘　　要：目的 探讨E26转录因子(E26 transformation-specific-1,Ets-1)在原发性卵巢癌中的 表达及其与微血管密度(microvessel density,MVD)的关系。方法 应用免疫组织化学链霉素抗生物 素一过氧化物酶复合法(streptomycin avidin-biotin-peroxidase complex,SP)检测32例原发性卵巢癌 组织中Ets-1的表达和MVD值。结果 卵巢癌组织中Ets-1的阳性表达率和MVD值明显高于癌旁 组织(P<0．001);Ets-1的表达和MVD值与原发性卵巢癌的FICO分期和组织学分级密切相关;有 淋巴结转移患者的Ets-1阳性表达率和MVD值高于无淋巴结转移患者(P<0．01);癌组织中Ets-1 的表达和MVD值密切相关,相关系数rs0．43(P<0．05)。结论 检测Ets-1的表达和MVD值可作为 了解卵巢癌生物学行为的参考指标。Objective To investigate the expression of E26 transformation-specific-1 （Ets-1） and its correlations with microvessel density （MVD） in primary ovarian carcinoma. Methods Streptomycin avidin-biotin-peroxidase complex （SP） was used immunohistochemistrically to detect the expression of Ets-1 and MVD in primary ovarian carcinoma. Results Within carcinoma tissue of primary ovarian carcinoma had higher expression of Ets-1 compared with neighbouring ovarian tissue（P〈0. 001）. Both Ets-1 and MVD well correlated with the FIGO stage and grade of primary ovarian carcinoma. Within carcinoma tissue,patients with metastases of omental lymph-nodes had higher expression of Ets-1 and MVD than patients without metastases. The correlation analysis showed that There was a positive correlation between Ets-1 and MVD （rs0. 43, P〈0. 05）. Conclusion The results show that the expression of Ets-1 can be one of the parameters for understanding of biological behavior in primary ovarian carcinoma.

关 键 词：原发性卵巢癌 肿瘤血管形成 病理性 E26转录因子 微血管密度 免疫组织化学 

分 类 号：R341.43[医药卫生—基础医学] R737.31