可溶性细胞间粘附分子-1(sICAM-1)在新生儿败血症早期诊断的价值  

Volue of Soluble Intercellular Adhesion Molecule-1 for early diagnosis of Septicemia of new-born

作　　者：谢兰芬[1] 骆志平[1] 黄仍颂[1] 黄浩[1] 黄仕春[1] 

机构地区：[1]广东省深圳市龙岗中心医院儿科,518116

出　　处：《邯郸医学高等专科学校学报》2005年第5期458-459,共2页Journal of Handan Medical College

摘　　要：目的探讨血清可溶性细胞间粘附分子-1(sICAM-1)在新生儿败血症早期诊断的价值。方法采用双抗体夹心酶联免疫吸附法测定26例败血症新生儿早期及恢复期血清中sICAM-1水平,病情早期同时采用免疫比浊法测定C-反应蛋白(CRP)及对照组24例非感染性疾病新生儿血清中sICAM-1水平。结果新生儿败血症组早期及恢复期血清sICAM-1水平高于对照组(P<0.01),急性期及恢复期差异无显著性意义(P>0.05),而急性期C-反应蛋白仅9例增高。结论血清sICAM-1测定可作为新生儿败血症早期诊断指标,但不能判断疗效。Objective To exploe the value of serum soluble intercellular adhesion molecule-1 （sICAM-1） for early diagnosis for septicemia of newborn. Methods To determine the sICAM-1 level of blood serum with sand-wich enzymelinked immunosorbent assay in 26 cases early and restoration stage of septicemia of newborn, meantime to determine C-reaction protein （CRP） of blood serum with immunologic test in early stage of septicemia of newborn, and determine the control group sICAM-1 level of blood serum in 24 cases noninfections diseases. Results The sICAM-1 level of blood serum in early and restoration stage of septicemia of new-born higher the control group （P〈0.01）, and there was no significant difference in acute and restoration stage （P〉0.05）, there were 9 cases that the CRP increased in acute stage. Conclusions The level of sICAM-1 of blood serum could be regarded as a index for early diagnosis of septicemia of newborn, but could not judge the effects.

关 键 词：败血症 细胞问粘附分子-1 新生儿 

分 类 号：R711.131[医药卫生—妇产科学]