Conversion of N-Acyl-4-phenyl/benzyl-oxazolidine-2-thiones into Thiol Esters in the Presence of EtSH-K2CO3  

作　　者：HU, Qi SUN, Ya-Ping WU, Yi-Kang 

机构地区：[1]State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2005年第11期1561-1563,共3页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075 and 20321202）, the Kn6wledge Innovation Project of the Chinese Academy of Sciences （No. KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502）.

摘　　要：N-Acyl-β-hydroxy-4-phenyl-oxazolidinethiones could be rapidly converted into their ethyl thiol esters in high yields by treatment with EtSH at 0 ℃ in CH3CN or 9 ： 1 （V ： V） THF-H2O in the presence of a catalytic amount of K2CO3.N-Acyl-β-hydroxy-4-phenyl-oxazolidinethiones could be rapidly converted into their ethyl thiol esters in high yields by treatment with EtSH at 0 ℃ in CH3CN or 9 ： 1 （V ： V） THF-H2O in the presence of a catalytic amount of K2CO3.

关 键 词：chiral auxiliary cleavage thiol ester ALDOL 

分 类 号：O622.4[理学—有机化学]