生物隋性纳米粒子的体内分布、移行和排泄  

Distribution, Migration and Excretion of Bio-Inert Nano-Particles in vivo

作　　者：杨留中[1] 孙岚[1] 张英鸽[1] 

机构地区：[1]军事医学科学院毒物药物研究所纳米药理毒理学重点实验室,北京100850

出　　处：《生物技术通讯》2005年第5期525-527,共3页Letters in Biotechnology

基　　金：国家自然科学基金项目(90406024-7)

摘　　要：给小鼠或兔静脉注射印度墨水或纳米活性炭,取标本进行病理观察或取胆汁和尿液制备涂片进行电镜观察,以研究生物惰性纳米粒子在体内的分布、移行及其排泄。结果在病理切片中发现纳米粒子除广泛分布于网状内皮系统外,也可见于胃肠道上皮细胞、杯状细胞等部位;电镜观察发现胆汁及尿液中存在大量纳米粒子。以上结果表明,生物惰性纳米粒子可在体内进行再分布及通过尿液、胆汁和杯状细胞排出体外。To study the distribution, migration and excretion of bio-inert nano-particles in vivo. Activated carbon nanoparticles and Indian ink were injected into veins of mice and tissue specimens were prepared for pathological study and smears of bile and urine were prepared for electron microscope observation. Bio-inert nano-particles can be found in the reticuloendothelial system as well as in the epithelial and goblet cells by light microscope and in the bile and urine by electron microscope. Bio-inert nano-particles in vivo can be redistributed and excreted by biliary and urinary ways and the goblet cells in intestinal epithelium.

关 键 词：纳米粒子 分布 排泄 

分 类 号：Q48[生物学—生理学] Q491