拟缺香茶菜二萜成分及细胞毒活性研究  

Studies on antitumor activity diterpenoids from Isodon excisoides

作　　者：王瀚[1] 丁兰[1] 刘国安[1] 杨东娟[1] 孙坤[1] 

机构地区：[1]西北师范大学生命科学学院,甘肃兰州730070

出　　处：《西北师范大学学报（自然科学版）》2005年第6期54-57,共4页Journal of Northwest Normal University(Natural Science)

基　　金：西北师范大学科技创新工程资助课题(NWNU-KJCXGC-02)

摘　　要：从甘肃产拟缺香茶菜(Isodon excisoides(Sun ex C.H.Hu)C.Y.Wu et H.W.Li)枝叶中分离得到5个贝壳杉烷型二萜化合物,并利用现代波谱学方法进行了结构鉴定,它们分别为Kamebacetal-A(Ⅰ)、Glaucocalyxin-A(Ⅱ)、Kamebanin(Ⅲ)、Wangzaozin-A(Ⅳ)和Leukamenin-E(Ⅴ).用SRB法分别进行了体外抗癌活性研究,结果表明,5种化合物对BEL-7402与HO-8910细胞株均具有较强的细胞毒活性.Five ent-kaurane diterpenoids were obtained from the dried leaves of Isodon excisoides （（Sun ex C. H. Hu）C.Y. Wu et H.W. Li）distributed in Gansu Province. Their structures were identified as Kamebacetal-A（ Ⅰ ）, Glaucocalyxin-A（ Ⅱ ）, Kamebanin（ Ⅲ ）, Wangzaozin-A（Ⅳ） and Leukamenin-E（ Ⅴ ） by spectroscopic means, respectively. The cytotoxicity was tested in vitro by SRB assay. The results indicate that the five compounds showed significant cytotoxic activity against BEL-7402 and HO-8910 cell lines.

关 键 词：拟缺香茶菜 对映-贝壳杉烷二萜 细胞毒活性 

分 类 号：Q946[生物学—植物学]