齐墩果醇酸对青霉噻唑蛋白致敏豚鼠过敏性休克的对抗作用  

Antagonistic effect of oleanolic acid on anaphylactic shock in guinea-pigs sensitized with penicilloyl-protein

作　　者：张莉蓉[1] 刘风芝[1] 马统勋[1] 乔海灵[1] 

机构地区：[1]河南医科大学临床药理学教研室

出　　处：《河南医科大学学报》1996年第1期28-31,共4页Journal of Henan Medical University

基　　金：河南省自然科学基金

摘　　要：研究了齐墩果醇酸（ＯＡ）对青霉噻唑（ＢＰＯ）蛋白致敏豚鼠过敏性休克的对抗作用。结果：豚鼠皮下注射ＯＡ，可明显降低ＢＰＯ－蛋白致敏豚鼠过敏性休克的发生率和死亡率，致敏对照组过敏性休克的发生率和死亡率均为１００％，ＯＡ５０，１００ｍｇ·ｋｇ－１·ｄ－１给药组过敏性休克发生率分别为７３％和６３％，死亡率分别为６３％和５５％；抑制致敏豚鼠血清抗ＢＰＯ抗体生成；降低肺组胺含量；抑制豚鼠ＰＣＡ反应及大鼠颅骨骨膜肥大细胞脱颗粒。提示：ＯＡ对抗青霉素过敏性休克作用机制与其抑制血清抗ＢＰＯ抗体生成，并降低组胺含量有关。The antagonistic effect of oleanolic acid (OA) on anaphylactic shock in guinea-pigs sensitized with penicilloyl (BPO)-protein was studied. The results demonstrated that OA could reduce the anaphylactic shock and death rates. In guinea-pigs sensitized with BPO-protein,OA 50,100 mg·kg-1 reduced the anaphylactic shock rates from l00% (sensitized control group) to 73% and 63% (OA pretreated group), and the death rates from l00% to 63% and 55%, respectively. OA had an inhibitory effect on the antibody formation in sensitized guineapigs. OA reduced the histamine contents in the lung tissues in the sensitized guinea-pigs. In addition, the homologous passive cutaneous anaphylaxis in guinea-pigs and the degranulation of mast cells of calvarial preiosteum in rats were siginificantly prevented by OA 50, 100mg·kg-1. The mechanism for antagonistic effect of OA on anaphylactic shock was related to the inhibition of the formation of the antibody and the reduction of the contents of the histamine.

关 键 词：齐墩果醇酸 青霉噻唑蛋白 过敏性休克 抗过敏药 

分 类 号：R976[医药卫生—药品] R978.11[医药卫生—药学]