胶原酶注入腰椎间盘突出物内及硬膜外腔溶解术疗效评价  

The Therapeutic Effect of Transdermal Collagenase Injection into Protrusion or Epidural Space for Lumbar Disc Herniation

作　　者：徐国松[1] 陈永林[1] 欧阳沙凡 

机构地区：[1]川北医学院附属医院广安市人民医院介入治疗中心,四川广安638000 [2]四川广能集团总医院放射科,四川广安638000

出　　处：《华西医学》2005年第4期686-687,共2页West China Medical Journal

摘　　要：目的:探讨腰椎间盘突出物(髓核)内及硬膜外腔注入胶原酶溶解术的疗效。材料和方法:在CT导引下经椎板间孔穿刺注入胶原酶治疗163例腰椎间盘突出症患者,其中62例实施硬膜外腔内注药,另一组101例实施突出物内注药。根据日本骨科学会制定的腰腿痛疗效判断标准[1],对两组病例术后疗效进行随访比较。结果:突出物(髓核)内注药法:优41例,占40.59%;良51例,占50.5%;可6例,占5.94%;差3例,占2.97%。硬膜外腔注药法:优14例,占22.58%;良28例,占45.16%;可13例,占20.97%;差7例,占11.29%。两组疗效进行χ2检验(χ20.005(3)=15.69,P<0.005)有显著差异。结论:突出物(髓核)内注药疗效明显,其效果优于硬膜外腔内注药。Objective： To compare the therapeutic effect of transdermal collagenase injection into the protrusion or epidural cavity for lumbar disc herniation. Method： Total 163 cases of lumbar disc herniations were randomly divided into two groups： the first group, injection of collagenase into the epidural cavity was carried out in 62 cases under the guidance of CT; and the second group of 101 cases into the protrusions. The curative effects were compared during the 9 months follow- up after operation, according to the standard by the thopaedic Association of Japan. Results： In the first group, there were 14 cases having excellent outcomes （22.58%）; 28cases with good outcomes （45.16%） ; 13 cases with moderate improvement （20.97%） ; and 7 cases with poor outcomes （ 11.29% ）. Compared with it, the pecond group, 41 cases had excellent outcomes （40.59%） ; 51 cases with good ouecomes （50.5%）; 6 cases with moderate improvement （5.94%）; and 4 cases with pour outcomes （2.97%）. Chi - Square test shows that there was significant difference of the curative effects between the two groups （ P 〈 0. 005 ）. Conclusions： The curative effect of injection into protrusions was much better than that into the epidural cavity.

关 键 词：CT导向 胶原酶 椎间盘突出 疗效评价 

分 类 号：R681.53[医药卫生—骨科学]