肺炎儿童血清皮质醇、胰岛素样生长因子-Ⅱ的检测及临床意义  

Clinical Significance of change of serum Cortisol (COR) and Insulin - like growth factor Ⅱ (IGF-Ⅱ) in children with bronchopneumonia

作　　者：黄刘炜[1] 蓝菊红[1] 管丽华[2] 雷后兴[2] 

机构地区：[1]浙江省丽水市中心医院,323000 [2]浙江省丽水市人民医院,323000

出　　处：《浙江临床医学》2005年第11期1136-1137,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨血清皮质醇、胰岛素样生长因子-Ⅱ在急性支气管肺炎患儿中的含量变化及临床意义。方法采用放射免疫法(RIA)测定60例急性支气管肺炎患儿(肺炎组)和30例健康儿童(对照组)血清中皮质醇(COR)、胰岛素样生长因子-Ⅱ(IGF-Ⅱ)的含量。结果肺炎组患儿血清COR、IGF-Ⅱ分别为(87.20±54.60)μg/L、(0.90±0.23)ng/ml;对照组为(47.00±9.83)μg/L、(0.66±0.11)ng/ml,肺炎组较对照组明显增高,两组受检者血清含量间差异有非常显著性(P<0.01)。而轻型肺炎组患儿血清COR、IGF-Ⅱ分别为(73.70±45.99)μg/L、(0.83±0.18)ng/ml;重型肺炎组为(126.20±34.99)ug/L、(1.08±0.29)ng/ml,重型肺炎组较轻型肺炎组明显增高,两组受检者血清含量间差异也有非常显著性意义(P<0.01)。结论检测肺炎患儿血清中COR、IGF-Ⅱ的水平对治疗有一定的临床意义。Objective To investigate the clinical significance of change of serum Cortisol（COR） and Insulin - like growth factor Ⅱ （IGF -Ⅱ ） in children with bronchopneumonia. Methods 60 children with acute pneumonia（ pneumonia group） and 30 healthy children （contrast group） were tested for the levels of serum COR and IGF - Ⅱ by radioimmunoassay. Results： The levels of serum COR and IGF -Ⅱ in pneumonia group were significant higher than that of in contrast group respectively （87.20 ± 54,60 vs 47. 00 ± 9.83 （μg/L）, 0.90 ± 0.23 vs 0.66 ± 0.11 （ ng/ml ）, P 〈 0.01 ）. In pneumonia group , 60 case were divided into severe group and mild group according to severity of pneumonia. The levels d sertml COR and IGF -Ⅱ in severe cases were significant higher than that of in mild group respectively （ 126.20 ±34.99 vs 73.70 ± 45.99 （μg/L）, 1.08± 0.29 vs 0.83 ± 0.18 （ ng/ml ）, P 〈 0.01 ） . Conclusion Determination of serum COR and IGF - Ⅱ have clinical significance in the treatment of child with pneumonia.

关 键 词：肺炎 皮质醇 胰岛素样生长因子-Ⅱ儿童放射免疫分析 

分 类 号：R725.6[医药卫生—儿科]