吴茱萸次碱对胃肠道运动影响的实验研究  

Effects of rutecarpine on movement of gastrointestinal tractin experimental animals

作　　者：王晓虎[1] 吴巍巍[1] 刘保林[1] 

机构地区：[1]中国药科大学中药学院中药药理教研室

出　　处：《中国临床药理学与治疗学》2005年第10期1104-1107,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的：研究吴茱萸次碱对胃肠道运动的影响，并就其作用机制进行初步探讨。方法：考察吴茱萸次碱对正常小鼠肠道推进的影响，并分别以新斯的明、胃复安或利血平制作了小鼠胃肠道运动亢进的模型，观察了吴茱萸次碱的拮抗作用；豚鼠离体肠管在乙酰胆碱或组胺的刺激下发生收缩，在此基础上，了解吴茱萸次碱的抑制作用。结果：吴茱萸次碱抑制正常小鼠小肠推进和新斯的明所致的小肠运动亢进，但对后者的作用更为明显；对甲氧氯普胺和利血平所致的胃排空亢进表现出显著的抑制作用，同时有效地对抗了乙酰胆碱或组胺对豚鼠离体肠管的收缩作用。结论：吴茱萸次碱能抑制小鼠胃肠运动功能，可能与其对抗胆碱能神经对胃肠道运动的支配有关。AIM： To evaluate effects of rutecarpine on the movements of gastrointestinal tract in experimental animals. METHODS： In mice, the accelerated movement model of intestinal transit was induced by neostigmine, and metoclopramide or apoplon was applied to induce the accelerated gastric emptying movements. Acetylcholine or histamine was used to induce the contractions occurring in the isolated ileum from guinea pigs. RESULTS： Rutecarpine inhibited normal intestinal transit and demonstrated more effective suppression on the accelerated movement induced by neostigmine in mice; metoclopramide and apoplon induced-accelerated gastric emptying movements were also significantly inhibited by rutecarpine in a dose-dependent manner. Meanwhile rutecarpine significantly inhibited the isolated ileum contractions induced by acetylcholine or histamine. CONCLUSION： Rutecarpine is an effective inhibitor to intestinal motility and this activity is probably mediated by its antagonistic effects on the cholinergic nerve or its responsible modulations.

关 键 词：吴茱萸次碱 胃排空 小肠推进 回肠 乙酰胆碱 组胺 

分 类 号：R373.2[医药卫生—病原生物学]