一种白僵菌代谢产物BCEF0083对慢性应激抑郁大鼠下丘脑、垂体精氨酸加压素含量及海马GR mRNA表达的影响  

Effect of BCEF0083, bioactive compounds from Entomogenous fungi, on AVP content of hypothalamus, pituitary and expression of glucocorticoid receptor mRNA of hippocampus in chronic unpredictable stress model of depression in rats

作　　者：阚红卫[1] 程燕[1] 周兰兰[1] 明亮[1] 

机构地区：[1]安徽医科大学药理教研室

出　　处：《中国临床药理学与治疗学》2005年第10期1143-1146,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：安徽省科技厅自然科学基金资助课题(№44415)

摘　　要：目的：研究一种白僵菌代谢产物(BCEF0083)对实验性慢性应激抑郁大鼠下丘脑、垂体精氨酸加压素(AVP)含量及海马糖皮质激素受体mRNA(GRmRNA)表达的影响。方法：采用慢性不可预见性应激法造成大鼠抑郁模型，用放射免疫分析法测定抑郁模型大鼠下丘脑、垂体AVP含量，采用逆转录-聚合酶链反应(RT-PCR)法测定海马GR mRNA表达。 结果：BCEF0083可降低慢性应激抑郁大鼠下丘脑、垂体AVP含量，上调海马GR mRNA表达。结论：BCEF0083的抗抑郁作用可能与其降低慢性应激大鼠下丘脑、垂体AVP含量及上调海马GR mRNA表达有关。AIM： To study the effect of bioactive compounds from Entomogenous fungi （BCEF0083）, on AVP content of hypothalamus, pituitary and expression of glueocorticoid receptor （GR） mRNA of hippocampus in chronic unpredictable stress model of depression in rats. METHODS： The depression animal model was induced by chronic unpredictable stress. The effect of BCEF0083 on AVP content in hypothalamus and pituitary was tested by radioimmunoassay. RT-PCR was used to test the expression of GR mRNA in hippocampus. RESULTS：BCEF0083 decreased the AVP content of hypothalamus and pituitary in chronic unpredictable stressed rats, and increased the expression of GR mRNA of hippocampus in chronic stressed rats. CONCLUSION： BCEF0083 exhibits antidepressant effect by attenuating the stimulated function of hypothalamus-pituitary-adrenal axis in chronic unpredictable stress model of depression in rats.

关 键 词：慢性应激 白僵菌 精氨酸加压素 糖皮质激素受体 

分 类 号：R965.1[医药卫生—药理学]