Met-RANTES对内皮细胞与T细胞相互作用的影响  

Influence of Met-RANTES upon interactions of T lymphocytes and endothelial

作　　者：孙志成[1] 郑红[2] 李世荣[2] 吴军[2] 

机构地区：[1]天津市武警医学院附属医院整形美容中心,天津300162 [2]重庆市沙坪坝高滩岩第三军医大学西南医院烧伤研究所,重庆400038

出　　处：《中国免疫学杂志》2005年第11期846-849,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金资助(No.30170900)

摘　　要：目的:探讨趋化因子拮抗剂Met-RANTES对内皮细胞与异体T细胞趋化、黏附作用的影响。方法:采用T细胞与血管内皮细胞混合培养的方法,观察使用趋化因子拮抗剂Met-RANTES干预前后内皮细胞趋化因子的表达,以及血管内皮细胞对T细胞趋化、黏附率的变化。结果:血管内皮细胞与T细胞混合培养可见内皮细胞表达RANTES、MCP-1及MIP-1α,RAN-TES的表达率增高。趋化因子拮抗剂Met-RANTES可以显著影响内皮细胞对T细胞的趋化和黏附。结论:趋化因子在淋巴细胞趋化及黏附内皮细胞的过程中发挥着重要作用,而趋化因子拮抗剂Met-RANTES可以显著影响内皮细胞与异体T细胞的趋化与黏附作用。Objective：To study the influence of chemokine receptor blocker Met-RANTES upon endothelium adhesion and chemotaxis functions in response to T lymphocyte.Methods：In vitro,endothelium and T cell were mixed culture, which was used to observe endothelium adhesion and chemotaxis effect on T lymphocyte and expression of chemokine from endothelium, before and after using Met-RANTES. Results： When endothelium and T cell were mixed culture, endothelium expressed RANTES, MCP-1, MIP-1α, and the expression of RANTES was the largest. Met-RANTFS could decrease endothelium adhesion and chemotaxis functions to T lymphocyte. Conclusion： Chemokines play an importam role in endothelium adhesion and chemotaxis functions in response to T lymphocyte. Met-RANTES can decrease endothelium chemotaxis to T cell and then block endothelium firm adhesion with it.

关 键 词：Met-RANTES 内皮细胞 T细胞 

分 类 号：R392.4[医药卫生—免疫学]