缬沙坦对存活心肌间质纤维化及凋亡的影响  

The Effect of Valsartan on Interstitial Fibrosis and Apoptosis in Viable Myocardium

作　　者：李东野[1] 李薇薇[1] 夏勇[1] 钱文浩[1] 朱红[1] 

机构地区：[1]江苏徐州医学院心研所-附院心内科,徐州221002

出　　处：《复旦学报（医学版）》2005年第6期725-728,共4页Fudan University Journal of Medical Sciences

基　　金：江苏省高校自然科学研究计划项目(03KJB320145)

摘　　要：目的评价缬沙坦对心肌缺血后心功能、心室重构的影响。方法建立家兔慢性冬眠心肌(CHM)模型,研究缬沙坦对CHM组织间质纤维化、凋亡及心功能的影响。结果缬沙坦可抑制CHM组织间质纤维化、减少凋亡细胞、改善心功能。结论缬沙坦可逆转心肌缺血后心室重构,对存活心肌有保护作用。Purpose To evaluate the pharmaceutical effect of valsartan on ventricular function reconstitution and after myocardium ischemia. Methods The rabbit model of chronic hibernating myocardium was established and the influences of valsartan on interstitial fibrosis, myocardial apoptosis and ventricular function were studied. Results Valsartan could inhibit interstitial fibrosis, decrease apoptotic ceils and ameliorate ventricular function. Conclusions These results suggest that valsartan is able to reverse reconstitution and preserve viable myocardium.

关 键 词：缬沙坦 慢性冬眠心肌 心室重构 凋亡 家兔 

分 类 号：R540.45[医药卫生—心血管疾病]