前列腺素E_1治疗糖尿病性动脉硬化闭塞症疗效观察  

A Clinical Observation of Prostaglandin E_1 on Diabetic Arteriosclerosis Obliterans

作　　者：侯旭晖[1] 张静菊[1] 杨松柏[1] 尹健[1] 

机构地区：[1]吉林大学中日联谊医院血管外科,吉林省长春市130033

出　　处：《中国全科医学》2005年第22期1881-1882,共2页Chinese General Practice

摘　　要：目的探讨前列腺素E1(PGE1)治疗糖尿病性动脉硬化闭塞症(DASO)的临床效果。方法回顾性分析了1995～2003年我院收治的84例DASO患者的临床诊治经过,评价PGE1的治疗效果。结果PGE1治疗组65例患者中,优16例,良26例,进步15例,无效8例;对照组19例患者中,优2例,良4例,进步6例,无效7例,两组患者疗效间差别有显著性意义(P<0.05)。结论PGE1可扩张血管、增加肢体血流量和抑制血小板聚集,是治疗DASO的有效药物。Objective To discuss the therapeutic efficacy of PGE1 in the treatment for DASO. Methods A retrospective study was made on the clinical progress and therapy of 84 patients with DASO from 1995 to 2003 and the therapeutic efficacy was evaluated. Results In PGEl treatment group （65 cases）, 16 were excellent （24.6%）, 26 were good （40.0%）, 15 were progressive （23.1%） , and 8 were useless （12.3%）. In the control group （ 19 cases）, 2 were excellent （10.5%）, 4 were good （21.1%）, 6 were progressive （31.6%）, and 7 were useless （36. 8%）. There was significant difference between the two groups （P〈0.05）. Conclusion PGE1 can dilate blood vessels, suppress the aggregation of the blood platelet, and improve microcirculation and velocity of blood flow in lower limbs. PGE1 is effective in treating DASO.

关 键 词：前列地尔 糖尿病性动脉硬化闭塞症 

分 类 号：R587.2[医药卫生—内分泌] R972.4[医药卫生—内科学]