动态IP_3-Ca^(2+)振荡模型的数值分析  

THE NUMERICAL STUDY OF DYNAMICAL IP_3-Ca^(2+) OSCILLATION MODEL

作　　者：严传魁[1] 刘深泉[1] 

机构地区：[1]华南理工大学数学科学学院应用数学系,广州510640

出　　处：《生物物理学报》2005年第5期339-344,共6页Acta Biophysica Sinica

基　　金：国家自然科学基金项目(19902005);国家自然科学基金重点项目(10432010)

摘　　要：通过改进J.W.Shuai和P.Jung钙振荡模型,得到与IP3浓度相关的动态IP3-Ca2+振荡模型。利用改进模型,数值分析依赖性参数#和钙通道数目N对Ca2+振荡的影响,得到Ca2+振荡关于参数#的分叉图、Ca2+振荡与IP3振荡的一致性、钙通道数目N对Ca2+振荡的影响等。这些模型结果显示了Ca2+振荡的特性。In this paper, with help of improved J.W.Shuai and P.Jung Ca^2＋ oscillation model, the dynamical IP3-Ca^2＋ oscillation model connected with varying IP3 concentration was obtained. Using revised model, the effect of dependence parameter A and number of Ca^2＋ channels N on Ca^2＋ oscillation was analyzed. The bifurcation diagrams of Ca^2＋ oscillation as a function of λ was found. The coherence of Ca^2＋oscillation and IP3 oscillation was gained and the effect of number of Ca^2＋ channels N on Ca^2＋ oscillation was studied. These model results reveal the properties of Ca^2＋ oscillation.

关 键 词：Ca^2+振荡 IP3 IP3R/Ca^2+通道 分叉 

分 类 号：Q612[生物学—生物物理学]