新骨架N_3S型肾功能显像剂的制备及其在小鼠体内的生物分布研究  

Synthesis of new N_3S pseudo-peptide complex and its biodistribution in mice

作　　者：叶海鸿[1] 韩见生[1] 刘春萍[1] 李华[1] 张华北[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《核技术》2005年第11期867-871,共5页Nuclear Techniques

基　　金：教育部回国人员启动基金资助

摘　　要：以巯基乙酸为初始原料,通过5步反应设计合成了一个新的N3S型类肽配体,其结构经谱学鉴定(IR,1HNMR,元素分析);并进行了99Tcm放射性标记,研究了在小鼠体内的生物分布特征。活性实验结果表明,99Tcm-MVGQ具有较高的肾初始摄取和较快的血清除速度,肾清除很快,具有成为新型肾功能显像剂的潜力。A new target chelator was synthesized through five steps with mercaptoacetic acid as primitive materials, which was identified on the basis of the spectroscopic data, such as IR, IHNMIL and elementary analysis. The chelator was labeled with technetium- 99m and its biological activities in mice given in %ID/g values were determined to explore new renal imaging agent. The bio-distribution results in mice indicate that ^99Tcm-MVGQ has high kidney uptake as well as quick blood and kidney clearance, thus showing promising application as an ideal kidney imaging agent.

关 键 词：肾功能显像剂 ^99Tcm放射性标记配体 生物分布 

分 类 号：R916.1[医药卫生—药学] R981.9