胎儿肠道Cajal间质细胞的发育  

Development of interstitial cells of Cajal in fetal intestines

作　　者：吴小红[1] 王宝西[1] 王茂贵[1] 

机构地区：[1]第四军医大学唐都医院儿科,陕西西安710038

出　　处：《第四军医大学学报》2005年第21期1971-1974,共4页Journal of the Fourth Military Medical University

摘　　要：目的:研究胎儿肠道Cajal间质细胞(interstitial cells of Cajal,ICC)分布及发育情况. 方法: 搜集中止妊娠3～8 mo胎儿标本12份,采用酪氨酸激酶受体(c-kit)抗体免疫组织化学方法标记胎儿肠道ICC. 结果: ①ICC分布于肠肌间神经丛、纵肌和环肌层面;②不同胎龄胎儿标本,不同层面ICC分布存在差异,随胎龄增加,ICC数目增多;③ICC的呈现按一定时间顺序,肠肌间神经丛,ICC呈现最早,肌内次之,深肌丛较晚;④ICC胞体逐渐增大,足突延长并互相连接,形成细胞间网络结构. 结论: 胎儿肠道ICC主要分布肠肌间神经丛周围,不同胎龄ICC分布及发育存在差异,不同层面ICC分布不同,随着胎龄增加,ICC数目增多,逐渐形成网络结构.AIM： To study the development and distribution of interstitial cells of Cajal （ICC） in fetal intestines. METHODS： Twelve samples of gestation ICC from 3 -4 months were collected, c-kit immunohistochemistry were used in the experiment. RESULTS： （1）ICC was distributed in circular muscle layer, longitudinal muscle layer and the myenteric plexus. （2）The distribution of ICC varied throughout the intestines with different gestational ages and intestines layers. The number of ICC increased with the gestational age. （3）ICC appeared first along the myenteric plexus, then in muscle layer and then in deep muscular plexus. （4）With the increase of gestational age, the cell body enlarged and its foot processes elongated. ICC formed network gradually. CONCLUSION： The development of ICC varies throughout the intestines with the different gestational ages and intestines layers. ICC are located primarily in the myenteric plexus of Auerbach. The number of ICC increases and ICC form network gradually with the increase of gestational age.

关 键 词：CAJAL间质细胞 肠 分布 胎儿 

分 类 号：R322.451[医药卫生—人体解剖和组织胚胎学]