不同粒径的水飞蓟素固体脂质纳米粒口服吸收比较研究  

Effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparticles

作　　者：何军[1] 侯世祥[2] 奉建芳[1] 蔡本琴 

机构地区：[1]上海医药工业研究院,上海200437 [2]四川大学华西药学院,四川成都610041 [3]广西花红药业有限责任公司,广西柳州545007

出　　处：《中国中药杂志》2005年第21期1651-1653,共3页China Journal of Chinese Materia Medica

基　　金：863计划(2001AA218011);上海市纳米科技与产业发展促进中心项目(0143nm063)

摘　　要：目的:考察不同粒径的固体脂质纳米粒对大鼠口服吸收水飞蓟素的影响。方法:以山榆酸甘油酯为载体材料,分别制备了150,500,1 000 nm 3种粒径的水飞蓟素固体脂质纳米粒,给大鼠灌胃后,采用RP-HPLC测定不同时间点血药浓度,数据经3p97软件进行处理。结果:口服150 nm水飞蓟素固体脂质纳米粒后的AUC分别是500,1 000 nm的2.08,2.54倍(P<0.05),这表明150 nm固体脂质纳米粒的生物利用度明显高于其他2种制剂。结论:固体脂质纳米粒粒径对水飞蓟素的口服吸收有着显著影响。Objective： To invetigate effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparuicles. Method： Solid lipid nanoparticles（SLN） of various sizes（150 nm,500 nm and 1 000 nm） using Compritol 888 ATO as the material and silymarin（SM） as a model drug were prepared. Silybinin concentration in plasma of rats were determined by RP-HPLC with UV detector. The main pharmacokinetic parameters were calculated by 31097. Result： Results showed that the AUC of 150 nm SLN was 2.08 fold that of 500 nm SLN and 2.54 fold of 1 000 nm SLN treated orally to rats（ P 〈 0.05）. The oral bioavailability of 150nm SLN was remarkably higher than the other two size SLN. Conclusion. This has important implications in designing of SM-SLN as a new oral drug delivery system.

关 键 词：水飞蓟素 固体脂质纳米粒 生物利用度 

分 类 号：R283[医药卫生—中药学]