多巴胺受体拮抗剂对AD大鼠的实验治疗学研究  

EXPERIMENTAL THERAPUTIC STUDIES OF DOPAMINE RECEPTOR ANTAGONISTS ON RAT MODEL OF ALZHEIMER'S DISEASE

作　　者：吴云明 胡刚 

出　　处：《徐州医学院学报》1996年第1期8-11,共4页Acta Academiae Medicinae Xuzhou

基　　金：江苏省教委自然科学基金

摘　　要：应用行为学实验及放免方法，研究了多巴胺受体拮抗剂对阿尔茨海默氏症（ＡＤ）模型大鼠学习记忆能力、空间分辨能力的影响及对海马内乙酰胆碱（Ａｃｈ）含量、胆碱乙酰转移酶（ＣｈＡＴ）活性的影响。研究发现，选择性Ｄ２受体拮抗剂Ｓｐｉｐｅｒｏｎｅ在显著改善ＡＤ大鼠认知力的同时，增加海马内Ａｃｈ含量和ＣｈＡＴ活性。结果表明，Ｄ２受体拮抗剂对ＡＤ大鼠的认知障碍具有改善作用，此作用可能与其增强脑内胆碱能功能有关。Using the method of behavioral science and radio-immunological technique, the authors studied the effects of dopamine receptor antagonists on Alzheimer's disease (AD) model rats' capabilities of learning, memory, and spatial localization and the effects on acetylcholine (Ach) content and choline acetyltransfetase (ChAT) activity in the hippocampus. It was found that the selective D_2 receptor antgonist spiperone significantly improved their cognitive ability and enhanced the Ach content and ChAT activity in the hippocampus. The results indicate the therapeutic effect of D2 receptor antagonist on the cognitive ability deficit in AD rats may be exerted by enhancing tne Ach content and ChAT activity in the hippocampus.

关 键 词：早老性痴呆 药物疗法 多巴胺 受体拮抗剂 

分 类 号：R972[医药卫生—药品] R749.160.5[医药卫生—药学]