偏食低钙对大鼠心肌线粒体膜脂流动性的影响  

Influence of low calcium in monotonous diet on membrane lipid fluidity of myocardial mitochondria of rats

作　　者：盖丽云[1] 郭城浩 孙波[1] 康德仁[1] 王凡[1] 杨世杰[3] 

机构地区：[1]白求恩医科大学地方病研究所,长春130021 [2]青岛医学院中心实验室 [3]白求恩医科大学基础医学院中心实验室

出　　处：《中国地方病学杂志》1996年第2期79-81,共3页Chinese Jouranl of Endemiology

摘　　要：用克山病病区粮以模仿病区易感人群膳食组成的偏食饲料及在其中补充不同浓度的钙进行动物实验,观察对大鼠心肌线粒体膜脂流动性及生长代谢的影响。结果表明偏食饲料除低 Se 外,低钙特别突出,仅为常规食的1/20,偏食组动物血钙(总钙和游离钙)也明显低下。与加 Ca 组和常规食组比,偏食组大鼠心肌线粒体膜脂流动性明显降低(p<0.05或 p<0.01)。当在偏食饲料中补 Ca 600×10^(-6)时,动物血钙即明显升高,接近常规食组水平。当在偏食饲料中补 Ca800×10^(-6)时,即可达到常规食组水平,大鼠心肌线粒体膜脂流动性也接近常规食组水平。这表明偏食低钙在克山病心肌线粒体结构损伤乃至克山病心肌坏死发生中具有重要作用。In this experiment,membrane lipid fluidity of myocardial mitochondria and growth metabolism of rats were investigated by feeding grains from Keshan disease endemic area(namely monotonous diet that imitated the composition of diet for the susceptible population of Keshan disease)and supplemented with different level calcium in it.The results showed that this monotonous diet was besides low in sele- nium,still prominently low in calcium,it was only 1/20 of the stock diet.The level of plasma calcium(to- tal calcium and free calcium)was also significantly decreased in monotonous diet group.The membrane lipid fluidity of myocardial mitochondria of rat of monotonous diet group was significantly lowered than the groups which were supplemented with calcium and stock diet(P<0.05 or p<0.01).The level of plasma calcium was prominently increased and nearly to that of stock diet when supplemented with cal- cium 600×10^(-6).It reached the level of stock diet group when supplemented with calcium 800×10^(-6). Meanwhile,membrane lipid fluidity of myocardial mitochondria of rat was also nearly to the level of stock diet group.It was further confirmed that low calcium in monotonous diet plays an important role in structure damage of myocardial mitoehondria of Keshan disease and myocardial necrosis.

关 键 词：钙 心肌线粒体 膜脂流动性 克山病 

分 类 号：R542.302[医药卫生—心血管疾病]