他汀类药物对心血管的保护作用  

Beneficial cardiovascular effects of statins

作　　者：鲍晓[1] 关永源[1] 

机构地区：[1]中山大学中山医学院药理学教研室,广东广州510080

出　　处：《中国药理学通报》2005年第11期1289-1292,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30271503)

摘　　要：他汀类药物(statins)被研制出来的最初目的是降低血脂,但是现在发现它不仅具有降低血脂的作用,还具有很多其他的作用包括改善内皮细胞功能的紊乱,提高内皮源性一氧化氮合成酶的生物活性,抑制血管平滑肌细胞的增殖,抗氧化作用,抗炎作用,降低血压,逆转心血管系统的重构。充分理解statins的多效性作用及机制有利于它更好的在临床中被应用于心血管系统的预防和治疗。Pleiotropic effects of a drug are actions other than that for which the agents were developed. These effects may be desired or undesired, and may be unrelated to their primary mechanism. Statins were designed as a drug for reducing cholesterol, but now pleiotropic effect are found including improvement of endothelial dysfunction, inhancement of eNOS bioavailability antioxide effect, antiinflammatory properties and reduction of hypertension. Understanding those effects is important for treatment and prevention of cardiovascular disease.

关 键 词：他汀类药物 内皮源性一氧化氮合成酶 内皮细胞 功能紊乱 

分 类 号：R972.6[医药卫生—药品]