参赭助运合剂治疗系统性硬化症患者食管病变的疗效观察  

Clinical Efficacy of Shenzhe Zhuyun Mixture in Treating Esophageal Lesion in Patients with Systemic Sclerosis

作　　者：郭刚[1] 董淑云[1] 赵咏武[1] 李怡良[1] 陆春玲[1] 王振亮[1] 张庆昌[1] 

机构地区：[1]河北医科大学附属以岭医院风湿免疫科,石家庄050091

出　　处：《中国中西医结合杂志》2005年第11期971-974,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：河北省科技厅立项课题(No.012761199)

摘　　要：目的探讨参赭助运合剂对系统性硬化症(systemic sclerosis,SSc)患者食管病变的临床疗效。方法将符合入选标准的64例患者随机分为治疗组(参赭助运合剂+西沙必利片空白模拟剂)和对照组(西沙必利片+参赭助运合剂空白模拟剂),疗程2个月,观察患者临床疗效、食管病变证候积分以及立卧位钡剂食管通过时间、卧位食管钡剂排空指数、食管扩张处最宽横径值等的变化和对患者生存质量的影响。结果总有效率治疗组(96.9%)优于对照组(56.2%,P<0.01);两组治疗后食管病变证候均比治疗前均明显改善(P<0.01),且治疗组优于对照组(P<0.01);治疗组立卧位钡剂食管通过时间、卧位钡剂排空指数均改善(P<0.01),食管横径无明显改善;对照组除卧位钡剂食管通过时间有改善(P<0.01)外,其余指标均无明显变化;治疗组生存质量明显改善(P<0.01),对照组则无明显变化。结论参赭助运合剂可以增强SSc患者食管动力功能,是治疗SSc食管病变的有效中药复方。Objective To investigate the clinical efficacy of Shenzhe Zhuyun mixture （SZM） in treating esophageal lesion in patients with systemic sclerosis. Methods Sixty-four patients conforming to the inclusion criteria were randomly divided into 2 groups, the treated group and the control group treated respectively by SZM and cisapride, with the blank preparation imitating the contrast one, the treatment course to both groups was 2 months. The clinical efficacy, the changes in symptom scores of esophageal lesion, the orthostatic and elinostatic time of barium passing through esophagus, the clinostatic esophageal emptying index of barium , and the widest transverse diameter of ectatic esophageal segment, as well as the influence of treatment on patients＇ quality of life were observed. Results The total effective rate in the treated group was superior to that in the control group （96.9% vs 56.2%, P〈0.01）. Symptom of esophageal lesion was significantly improved after treatment in both groups （P 〈 0.01 ）, and the improvement in the treated group was better than that in the con- trol group （P 〈 0.01）. The time of Barium passing through esophagus, both orthostatic and clinostatic, and the esophageal emptying index of barium were improved in the treated group （P〈 0.01）, but the change of the widest transverse diameter of ectatic esophagus was insignificantly improved. While in the control group, excepting the clinostatic time of barium passing through was improved （P 〈 0.01）, the other indexes showed no obvious change. Patients＇ quality of life was significantly improved in the treated group, but improvement didn＇t revealed in the control group. Conclusion SZM can reinforce esophageal dynamic function in patients with systemic sclerosis, it can be an effective TCM prescription in treating esophageal lesion for them.

关 键 词：参赭助运合剂 系统性硬化症 食管病变 食管动力功能 

分 类 号：R259[医药卫生—中西医结合]