慢性缺氧-肺气肿大鼠膈肌生物力学特性变化  

Experimental studies on changes of biomechanical properties in diaphragm of rats with chronic hypoxia and emphysema

作　　者：王莉[1] 刘亚力[1] 徐春[1] 侍晓云[1] 

机构地区：[1]武警总医院内分泌科,北京100039

出　　处：《武警医学》2005年第11期814-817,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的复制大鼠缺氧-肺气肿模型,测定膈肌条生物力学特性,单个膈肌细胞的粘弹特性。方法制备慢性缺氧和肺气肿模型,检测膈肌条的收缩与疲劳特性,细胞微管吸吮系统测定单个膈肌细胞的粘弹特性。结果缺氧-肺气肿组颤搐收缩张力(Pt)和强直颤搐收缩张力(Po)显著下降,疲劳持续时间延长,力-频率曲线明显右移,缺氧-肺气肿组粘弹系数K1,K2,μ较对照组相应值明显降低,相差显著。结论缺氧-肺气肿大鼠膈肌疲劳与收缩特性减低,大鼠单个膈肌细胞的粘弹系数下降。Objective To investigate the mechanical characteristics of diaphragmatic strip and the viscoelastic properties of single diaphragmatic cells in rat models of hypoxia- emphysema. Methods The rat models of hypoxia , emphysema and hypoxia - emphysema were developed. The contractility and fatigue properties of isolated diaphra^atic muscles, and the viscoelastic properties of rat diaphragmatic cells were assessed. Results The increases in twitch tension and tetanic tension, and the decrease in half- relaxation time in emphysema and emphysema- hypoxia rats were more significant than those in hypoxic rats and controls. The force - frequency curve was right shifted in emphysema and emphysema - hypoxia rats. The viscoelastic properties K1, K2 and μ of cells in emphysema and emphysema - hypoxia group were lower than those in hypoxia and control groups. Conclusion The contractility and fatigabihty of diaphragma are reduced in hypoxia- emphysema rats. Viscoelastic properties of single diaphragmatic cells are decreased change in emphysema rats.

关 键 词：生物力学 膈肌 缺氧 肺气肿 

分 类 号：R563.3[医药卫生—呼吸系统] R318.01[医药卫生—内科学]