深部真菌感染310株及其耐药性分析  

Analysis of distribution and drug resistance of 310 fungus strains resulting in deep infections

作　　者：侯哲[1] 郑辉[1] 马艳华[1] 洪小京[1] 

机构地区：[1]武警广东总队医院检验科,广州510507

出　　处：《武警医学》2005年第11期817-819,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的了解310株深部感染真菌的菌群分布及药物敏感性状况,为临床治疗提供参考依据。方法所分离的真菌用ID3 2C鉴定真菌,用ATB FUNGUS进行药敏试验。结果310株真菌共有9种,以白色念珠菌为主。药敏结果显示,真菌对5-F胞嘧啶、两性霉素B、制霉菌素敏感率较高,均>90%。而对咪康唑、益康唑和酮康唑的敏感率相对较低。结论深部真菌感染主要由白色念珠菌、热带念珠菌、克柔念珠菌引起。对5-F胞嘧啶、两性霉素B、制霉菌素敏感率较高,是治疗深部真菌感染首选药物。Objective To investigate the distribution and the drug resistance of the fungi which cause deep infections. Methods The isolated fungi were identified with ID32C and drug susceptibility tests were conducted by using ATB FUNGUS.Results Totally 9 species were identified from 310 strains of deep fungi, predominantly Candida albicans . The total sensitivities of 310 strains to 5 - fluorocytosine,amphoteriein B, and myeomyein were 〉 90%, but lower to mieonazole, econazole, and ketoconazole. Conclusions The dominant pathogenic fungi which cause deep infection are Candida albicans, Candida tropicalis and Candida. krusei . 5 - Fluorocytosine , amphoteriein B useful and myeomyein are most effective against the pathogenic fungi and remain to be the most drugs to treat deep infections.

关 键 词：真菌 深部感染 药敏试验 

分 类 号：R519[医药卫生—内科学] R181.34[医药卫生—临床医学]