大鼠原位肝脏移植术后肝叶坏死  

Hepatic necrosis after orthotopic liver transplantation in the rat

作　　者：朱峰[1] 沈克震[1] 杨振林[1] 张浩[1] 王文擘[1] 柯庆红[1] 郑树森[1] 

机构地区：[1]浙江大学医学院附属第一医院肝胆外科,浙江杭州310003

出　　处：《医学研究生学报》2005年第11期992-994,共3页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30371358);浙江省自然科学基金资助项目(批准号:491010-N20204ZB0212)

摘　　要：目的:探讨大鼠原位肝移植术后肝叶坏死的原因以及预防措施。方法:应用Lew is大鼠和BN大鼠分别作供、受者,采用Kam ada“双套管法”行大鼠原位肝移植50次,对所有死亡大鼠进行尸体解剖,分析其死亡原因。结果:术后10只大鼠死于肝叶坏死。2只死于门静脉主干栓塞,全肝灰黄色、坏死。8只死于门静脉分支栓塞,其中左支栓塞5只,右支栓塞1只,右后叶分支门静脉栓塞2只。结论:肝叶坏死是大鼠肝移植术后后期死亡的主要原因。防止肝上下腔静脉吻合口狭窄、肝叶扭转和预防感染是防止门静脉及其分支栓塞的关键。Objective： To investigate the causes of hepatic necrosis after orthotopic liver transplantation in the rats and to evaluate the preventive measures. Methods： A total of 50 orthotopic liver transplantation was performed in Lewis and BN rat according to Kamada＇s cuff technique. Autopsy was performed on every dead rat and the causes were analyzed. Results ： Ten rats died of hepatic necrosis after orthotopic liver transplantation. 2 of the 10 rats died of embolism of the portal vein, and the whole liver were grayyellow and necrotic. The rest 8 rats died of embolism of branches of the portal vein, 5 of the eight embolism were in the left branches of the portal vein, 1 in the right branches, and 2 in the right posterior branches of the portal vein. Conclusion： Hepatic necrosis was the main causes of later death after orthotopic liver transplantation in the rats. Hepatic necrosis was due to embolism of the branches or the trunk of the portal vein. To prevent embolism of the portal vein and its branches, it is essential to avoid twisting of the liver lobe, stenosis of anastomosis in the suprahepatic vena cava, and infection.

关 键 词：肝移植 肝叶坏死 门静脉栓塞 并发症 

分 类 号：R657.3[医药卫生—外科学]