子痫前期患者血雄激素水平的研究  

Serum androgen levels in women with pre-eclampsia

作　　者：刘锦霞[1] 吴元赭[1] 郑宁[1] 党洁民[1] 

机构地区：[1]南京军区南京总医院妇产科,江苏南京210002

出　　处：《医学研究生学报》2005年第11期1029-1030,1040,共3页Journal of Medical Postgraduates

摘　　要：目的:检测子痫前期患者血雄激素的水平,以探讨雄激素在妊娠高血压中的作用。方法:应用放免法检测24例子痫前期患者及30例正常妊娠者血睾酮(T)、游离睾酮指数(FTI)、硫酸去氢表雄酮(DHEAS)、性激素结合蛋白(SHBG)、雌二醇(E2)和空腹血浆胰岛素(FINS)水平。结果:子痫前期组患者血T水平、FTI高于对照组(P<0.05);FINS水平及FINS/FPG均高于对照组(P<0.05);SHBG水平比对照组明显降低(P<0.05);两组患者DHEAS、E2水平无差异,新生儿性别分布无显著性差异(P>0.05)。结论:子痫前期患者血雄激素水平升高可能与胰岛素抵抗(IR)有关,雄激素可能参与了妊娠高血压的发病过程。Objective： To evaluate androgen levels in women with Pre-eclampsia and to elucidate the effect of androgen on the pathogenesis of the disease. Methods ： Serum testosterone, free testosterone index , dehydroepiandrosterone sulfate, sex hormone binding globulin, estradiol and insulin levels were measured in 30 normal pregnant women （control group） and 24 patients with Pre-eclampsia. Results： Total testosterone levels, free testosterone index （FTI）were significantly higher in the Pre-eclampsia group than the control group. Serum insulin levels and INS/SG in the Pre-eclampsia group were higher than those in the control group. Serum sex hormone binding globulin levels in the Pre-eclampsia group were lower than those in the control group. There were no significant differences in dehydroepiandrosterone sulfate, neonatal sex distribution and estradiol concentrations between the two groups. Conclusion ： Androgen testosterone levels were significantly elevated in pregnant women in Pre-eclampsia, which may be related to the insulin resistance mechanism. Androgen may play a role in the pathogenesis of Preeclampsia.

关 键 词：子痫前期 雄激素 

分 类 号：R714.245[医药卫生—妇产科学]