冠心病心绞痛患者白细胞介素18水平的变化  

The Clinical Research of Interleukin-18 with Angina Pectoris Patients in Coronary Heart Disease

作　　者：张燕[1] 黎莉[2] 张运[2] 谭红伟[2] 马志勇[2] 王颖[2] 李静[2] 朱圆圆[2] 

机构地区：[1]解放军第88医院心内科,山东省泰安市271000 [2]山东大学齐鲁医院心内科,山东省济南市250012

出　　处：《中国动脉硬化杂志》2005年第4期500-502,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的测定冠心病不稳定型心绞痛和稳定型心绞痛外周静脉血中白细胞介素18的浓度,观察其与心绞痛的临床相关性。方法选择不稳定型心绞痛患者40例、稳定型心绞痛患者20例和对照组20例,均进行冠状动脉造影和超声心动图检查,采用酶联免疫吸附法测定外周血清白细胞介素18浓度。结果与对照组比较,心绞痛组患者白细胞介素18浓度明显增高,冠心病左心室射血分数≤50%组患者的白细胞介素18浓度显著高于左心室射血分数>50%组的心绞痛患者,但不稳定型心绞痛组与稳定型心绞痛组之间白细胞介素18浓度差异无统计学意义。结论白细胞介素18浓度随冠状动脉病变的发生和心功能降低而升高,但与动脉粥样硬化斑块的稳定性无关。白细胞介素18的浓度可能对冠心病心绞痛患者的诊断及预后有重要参考价值。Aim To detect the peripheral venous blood concentration of interleukin-18 in patients with coronary heart disease and angina pectoris and evaluate its clinical correlation with angina pectoris. Methods Eighty hosipitalized patients were enrolled in this research. Forty cases were unstable angina pectoris, twenty cases were stable angina pectcris, twenty cases were nonnat controls. All patients were performed with coronary artery angiography and Doppler echocardiography. Interleukin-18 was measured with ELISA methods, Results The concentrations of interleukin-18 in patients with coronary heart disease and angina pectoris were much higher than controls＇, patients with coronary heart disease and left ventricular ejection fraction≤50% had higher IL-18 concentrations than those 〉 50%, but there were no difference between unstable angina pectoris and stable angins pectoris. Conclusions The concentrtion of Interleukin-18 was increased with coronary arteriosclerosis and the decrease of left ventricular ejection fraction, but not related to the stability of atherosclerosis plaques. Interleukin-18 perhaps had important values in diagnosing coronary artery diseases.

关 键 词：内科学 冠心病的炎症机制 白细胞介素18 不稳定型心绞痛 稳定型心绞痛 左心室射血分数 动脉粥样硬化 

分 类 号：R5[医药卫生—内科学]