重症顽固性银屑病疗效不佳的相关因素分析  

Analysis on the factor of poor therapeutic effects in refractory psoriasis

作　　者：何玉清[1] 张锡宝[1] 罗权[1] 刘玉梅[1] 黄振明[1] 陈绍谦[1] 

机构地区：[1]广州市皮肤病防治所,广州510095

出　　处：《中国麻风皮肤病杂志》2005年第10期774-776,共3页China Journal of Leprosy and Skin Diseases

基　　金：广东省重点科技攻关项目(99050)

摘　　要：目的:探讨导致重症顽固性银屑病疗效不佳的相关因素。方法:采用回顾性前瞻研究方法,对40例重症顽固性银屑病患者初诊时填调查表,然后治疗并追踪随访1年,先将研究重点运用单因素非条件logistic回归分析方法进行研究,再将有意义的变量进行多因素非条件logistic回归分析。结果:40例患者有13例疗效不佳,单因素非条件logistic回归分析显示:心理因素中的焦虑、恐惧、负性生活事件刺激;生物物理因素中的感染、劳累、外伤;治疗因素中的系统用过糖皮质激素与重症顽固性银屑病患者疗效不佳有关,而性别、年龄、病程、家族史与疗效无关。进一步将有意义的变量进行多因素非条件logistic回归分析发现:焦虑、劳累、患感染性疾病、系统用过糖皮质激素是导致重症顽固性银屑病患者疗效不佳的重要因素。结论:焦虑、劳累、负性生活事件刺激、患感染性疾病、系统用过糖皮质激素是导致顽固性银屑病患者疗效不佳的重要因素。Objective： Tu analyze the risk factors of poor therapeutic effects in refractory psoriasis. Methods： In this retrospective cohort study 40 cases of psoriasis were followed up for one year. The risk factors of psoriasis were analyzed by univariate and multivariate logistic regression. Results： Of the 40 patients, 13 cases had poor therapeutic effects. By univariate analysis, the stress, depression, overwork, trauma, infections, treatment with systemic corticosteroids increased the risk of flare （ P〈0.05） ; however, sex, age, disease duration and family history were not associated with poor effects （ P〉0.05 ）. By multivariate logistic regression analysis the stress, overwork, using of systemic corticosteroids and infeections were the important risk factors for psoriasis flare （ P〈0.05 ）. Conclusion： Stress, overwork, infections, using of systenfic corticosteroids were the important risk factors for psoriasis flare. The psoriatic： patients should be advised to avoid these risk factors in order to prevent from diesase flare.

关 键 词：银屑病 相关因素 顽固性银屑病 疗效不佳 非条件LOGISTIC回归分析 相关因素分析 重症 银屑病患者 负性生活事件 糖皮质激素 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]