冻干辐照处理脐动脉血管物理性能的实验研究  

An Experimental Study of Lyophilize-irradiated Umbilical Artery Allograft Mechanical Behavior

作　　者：钱涛[1] 翁品光[1] 余正[1] 钱晶[1] 戴鸿贵[1] 

机构地区：[1]南京大学医学院附属鼓楼医院,南京大学物理系,江苏省中医院预防保健科,江苏省农科院原子能所

出　　处：《生物医学工程学杂志》1996年第1期62-66,共5页Journal of Biomedical Engineering

摘　　要：为寻找理想的同种异体小口径血管移植材料，１９９３年７月至１９９４年５月，采用冻干辐照方法处理人脐动脉血管，并与新鲜脐血管、单纯冻干脐血管进行物理性能的比较，结果表明，经冻干辐照处理之后，脐动脉血管的物理性能改善，弹性和顺应性都明显提高，能够满足移植血管物理性能方面的要求。To search for an ideal allograft as coronary artery bypass graft, from July, 1993 to May, 1994, we selected lyophilization-radiation as a met hod to modify human umbilical artery allograft. We had a comparative study to test mechanical behavior in three groups (Group Ⅰ. fresh allograft; group Ⅱ. freeze-dried allograft; Group Ⅲ. lyophilize-irradiated allograft). The testing range of pressure was 0-40 kPa. Compared with that of group Ⅰ, the elasticity of group Ⅱ and Ⅲ had improved within the testing range. Group Ⅱ had Ⅲ kept better pliability at higher pressure: at 10 kPa, the pliability (1/kPa) of group Ⅰ, Ⅱ, Ⅲ were (11. 82±4. 02)×10-3, (9. 03±2. 42)×10-3, (7. 00±1. 94)×10-3, respectively (Ⅱ vs Ⅰ: NS; Ⅲ vs Ⅰ: P<0. 01); at 25 kPa, they were (4. 68±2. 63)×10-3, (9. 24±2. 63)×10-3, (6. 66±1. 13)±10-3, respectively (Ⅱ vs Ⅰ: P<0. 001; Ⅲ vs Ⅰ: P <0. 05). We think this change of alograft pliability is benificial to coronary artery bypass graft. We consider after further research, this lyophilize-irradiated allograft has broad and glorious prospect of clinical application in the area of small caliber artery (especially in coronary artery bypass) transplantation.

关 键 词：血管移植 冻干辐照 物理性能 脐带动脉血管 

分 类 号：R654.3[医药卫生—外科学]