19（s）－IgM－TPHA检测先天梅毒及1例报告  

19(s)-IgM-TPHA test in diagnosis of early congenital syphilis and report of a case

作　　者：顾伟鸣[1] 张惠敏 张皓[1] 汤全贵[1] 乐嘉豫[1] 

机构地区：[1]上海市皮肤病性病防治中心,上海市杨浦区妇幼保健院

出　　处：《临床皮肤科杂志》1996年第2期72-74,共3页Journal of Clinical Dermatology

摘　　要：用梅毒螺旋体特异性抗体１９（ｓ）－ＩｇＭ＋ＴＰＨＡ检测方法，确诊１例出生４天新生儿患先天梅毒。其母在怀孕晚期患二期潜隐梅毒，分娩前２周给红霉素治疗，分娩后复查ＲＰＲ滴度不变而１９（ｓ）－ＩｇＭ滴度显著下降。治疗１１个月后母婴１９（ｓ）－ＩｇＭ均转阴。作者认为，１９（ｓ）－ＩｇＭ检测是一种先天梅毒确诊手段。此法还是判断梅毒治疗效果的敏感指标。Using 19(s)-IgM-TPHA test,a case with early congenital syphilis was diagnosed in a 4 day infant.The mother suffered from secondary latent syphilis during the late period of pregnancy.Before delivery the mother was treated with erythromycin for 2 weeks.After delivery the mother's blood sample was retested and the result showed that titre of RPR remained the same while that of 19(s)-IgM decreased greatly and both in the mother and child the test became negative at the 11 th month after treatment.The authors considered that 19(s)-IgM-TPHA test is a confirmatory indicator for detecting early congenital syphilis and is a sensitive test for evaluating therapeutic efficacy.

关 键 词：梅毒 先天梅毒 19(s)-IgM-TPHA 诊断 

分 类 号：R759.151[医药卫生—皮肤病学与性病学]