A NOVEL ZWITTERIONIC SILANE COUPLING AGENT FOR NONTHROMBOGENIC BIOMATERIALS  

作　　者：Yong-zhi Qiu Dou-yong Min Chi Ben Chi Ben Qiang Chen Si-cong Lin 

机构地区：[1]Research Center of Surface ＆ Interface Chemistry and Engineering Technology, Nanjing University, Nanjing 210093, China [2]College of Chemistry ＆ Environment Science, Nanjing Normal University, Nanjing 210097, China

出　　处：《Chinese Journal of Polymer Science》2005年第6期611-617,共7页高分子科学（英文版）

基　　金：This work was support by the Special Funds for Major State Basic Research Projects of China(G1999064705).

摘　　要：A novel silane coupling agent bearing sulfobetaine group, N,N-diethyl-N-（3-sulfopropyl）-aminopropyl- trimethoxysilane （DESATS）, was first designed, synthesized and characterized. Its solution property was studied by means of dynamic light scattering. DESATS was successfully bonded onto the surface of the glass and proved by ESCA. Platelet adhesion assay in vitro indicated that the nonthrombogenicity of glass slide modified with DESATS is greatly improved.A novel silane coupling agent bearing sulfobetaine group, N,N-diethyl-N-（3-sulfopropyl）-aminopropyl- trimethoxysilane （DESATS）, was first designed, synthesized and characterized. Its solution property was studied by means of dynamic light scattering. DESATS was successfully bonded onto the surface of the glass and proved by ESCA. Platelet adhesion assay in vitro indicated that the nonthrombogenicity of glass slide modified with DESATS is greatly improved.

关 键 词：Zwitterionic silane coupling agent Silicone-sulfobetaine Nonthrombogenic biomaterials 

分 类 号：O621.3[理学—有机化学]