重组（人）白细胞介素2对伤寒Vi荚膜多糖菌苗的免疫佐剂效应的实验研究  

STUDIES OF IMMUNO-ADJUVANT EFFECT OF rhIL-2 oN TY PHOID Vi-VACCINE IMMUNIZED MICE

作　　者：李郁英[1] 李玉兰[1] 安云庆[1] 程松高[1] 计国欣[1] 辜清吾[1] 

机构地区：[1]首都医科大学微生物学教研室,中国药品生物制品检定所

出　　处：《中国免疫学杂志》1996年第2期75-77,共3页Chinese Journal of Immunology

摘　　要：采用改良溶血空斑试验和间接血球凝集试验研究了重组人白细胞介素２（ｒｈＩＬ－２）对伤寒Ｖｉ荚膜多糖菌苗（简称Ｖｉ菌苗）免疫小鼠的特异性抗Ｖｉ菌苗抗体应答的影响及其与免疫保护作用的关系。结果表明：ｒｈＩＬ－２能增强Ｖｉ菌苗免疫小鼠的特异性抗体应答，具有明显的佐剂效应；且特异性抗体的水平与用伤寒菌株（Ｔｙ２５００９８）攻击的小鼠的免疫保护力呈正相关关系。提示ｒｈＩＬ－２可用做Ｖｉ菌苗的免疫佐剂以提高接种人群抗伤寒感染的免疫保护力。The immuno-adjuvant effect of rhIL-2 on typhoid Vi-vaccine immunized mice was studied. The results showed that rhIL-2 could increase the lever of specific anti-Vi antibody production when the specific humoral immunity function was tested by modified PFC test and indirect hemoagglutination test. RhIL 2 could also enhance the protective ability of typoid Vi-vaccine immunized mice when the mice challenged by Vi-positive Ty2 strain, Additionally,the protective percentage was positively correlated with the lever of anti-Vi antibody.

关 键 词：伤寒疫苗 Vi荚膜多糖菌苗 RHIL-2 PFC 

分 类 号：R392-33[医药卫生—免疫学] R516.303[医药卫生—基础医学]