生长激素分泌过多患者外周血淋巴细胞CD2　mRNA的表达  

THE CD2 mRNA EXPRESSION IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES FROM GROWTH HORMONE OVERSECRETED PATIENTS

作　　者：吕文戈[1] 郑德先[1] 张泽松[1] 许成素[1] 刘士廉[1] 史轶蘩[1] 金自孟[1] 

机构地区：[1]中国医学科学院基础医学研究所,中国协和医科大学,北京协和医院内分泌科

出　　处：《中国免疫学杂志》1996年第2期121-123,共3页Chinese Journal of Immunology

基　　金：国家自然科学基金

摘　　要：应用ＲＮＡ斑点杂交法，测定了１２例生长激素（ＧＨ）分泌过多患者及１０例正常人外周血淋巴细胞ＣＤ２ｍＲＮＡ的表达，发现患者ＣＤ２ｍＲＮＡ的表达较之正常人有显著下降，提示ＧＨ分泌过多对Ｔ淋巴细胞ＣＤ２ｍＲＮＡ的表达有显著影响。此结果为研究内分泌系统产生的肽类激素对免疫系统的影响提供了新的资料。The CD2 mRNA expression in human peripheral blood lymphocytes from 12 cases of growth hormone (GH)over secreted patients and 10 cases of normal adults was studied by using RNA dot-blot hybridization, Significant decline of the CD2 mRNA expression in the patients' peripheral blood lymphocytes was found. This result demonstrated that the CD2 mRNA expression in T lymphocytes was affected by the GH over expression.

关 键 词：生长激素 分泌过多 外周血 淋巴细胞 CD2 MRNA 

分 类 号：R584.02[医药卫生—内分泌]