严重烧伤后脏器损害机制与防治  

THE PATHOGENESIS AND TREATMENT OF PRGAN DAMAGE FOLLOWING SEVERE BURNS

作　　者：黄跃生[1] 杨宗城[1] 陈发明[1] 刘旭盛[1] 安静[1] 何宝斌[1] 杨建明 张超[1] 黎鳌[1] 

机构地区：[1]重庆第三军医大学西南医院

出　　处：《解放军医学杂志》1996年第1期20-23,共4页Medical Journal of Chinese People's Liberation Army

基　　金：军队医药卫生"八五"指合性课题

摘　　要：通过系列的临床前瞻性研究与动物实验，发现并从多方面进一步证实了严重烧伤早期各主要脏器均可发生损害；缺血和再灌流损伤、脏器水肿、内皮细胞损伤及多种炎症介质的异常释放，导致难以控制的介质病，是脏器损害的重要因素；延迟复苏快速补液和使用介质拮抗剂山莨菪碱及人参皂甙或一次性切痂是防治严重烧伤早期脏器损害的有效方法。The pathogenesis of postburn organ damage as well as the effective measures for its prevention and treatment were studied. The present clinical prospective studies and animal experiments revealed or further confirmed that all the main organs could be damaged in the early stage following severe burns. Findings of this serial studies strongly suggested that the uncontrollable 'mediator disease' resuIted from ischemic-reperfusion damage, swelling and edema of visceraI tissues, the endothelial cell damage and abnormal release mediators might be of importance in the pathogenesis of early PB organ damage。 Fast fluid infusion for delayed resuscitation, the use of the mediator antagonixtxanisodamine and gensinosides or escharectomy by one operation are effective in the prevention and treatment of organ damage in the early stage of severe burns。

关 键 词：烧伤 脏器损害 心脏损害 胃肠道损害 多器官衰竭 

分 类 号：R644[医药卫生—外科学]